專任-系統生物與生物資訊組   首頁 師資介紹 專任-系統生物與生物資訊組
徐 沺 生醫講座教授 Tien Hsu
從聘系所:
專線電話:03-4227151轉36115
傳真電話:
E-mail :tienhsu@ncu.edu.tw
學經歷

Curriculum Vitae

 

Bachelor, Department of Agricultural Chemistry, National Taiwan University, 1977-1981

PhD, Medical University of South Carolina, USA, 1983-1988

Postdoc, Department of Cellular and Developmental Biology, Harvard University, USA, 1989-1993

Assistant Professor – Professor, Hollings Cancer Center, USA, 1993-2009

Professor of Medicine, Boston University School of Medicine, 2009-2013

Professor of Systems Biology and Bioinformatics, National Central University, Taiwan, 2013-present

Dean, College of Heath Sciences and Technology, National Central University, Taiwan, 2014-present

論文著作區

Publications

Papers (since 2014):
(Hsu lab members in bold: undergraduate students¶; graduate students#; postdocs†)

48. Ignesti, M., Barraco, M., Nallamothu, G.†, Woolworth, J.A.#, Duchi, S., Gargiulo, G., Cavaliere, V. and Hsu, T.(2014) Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biology. 12:12. [IF: 6.97; 31/204, Biochemistry, Genetics, and Molecular Biology]

 

49. Lin, C.H.#, Dammai, V. Adryan, B. and Hsu, T. (2015) Interaction between Nm23 and the tumor supressor VHL. Naunyn-Schmiedeberg Arch. Pharm. 388: 143-152. [IF: 2.38; 204/773, Pharmacology]

50. Pritchett, T.L.†, Bader, H.L.†, Henderson, J. and Hsu, T.  (2015) Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory, and fibrotic lesions in the kidney. Oncogene34: 2631-2639. [IF: 8.56; 19/196, Oncology]

51. Hsu, T., Steeg, P. S., Zollo, M. and Wieland, T (2015) Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified (Editorial) Naunyn-Schmiedeberg Arch. Pharm. 388: 109-117. [IF: 2.38; 204/773, Pharmacology]

52. Kirschner, R, Hsu, T., Tuan, N.N., Chen, C.L. and Huang, S.L. (2015) Characterization of Fungal and Bacterial Components in Gut/Fecal Microbiome. Curr. Drug Metab. 16: 272-283. [IF: 2.98; 82/254 Pharmacology]

53. Romani, P., Papi, A., Ignesti, M., Soccolini, G., Hsu, T., Gargiulo, G., Spisni, E., and Cavaliere, V. (2016) Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein. Naunyn-Schmiedeberg Arch. Pharm. 389: 1171-1182. [IF: 2.38; 204/773, Pharmacology]

54. Bader, H.L.† and Hsu, T. (2016) Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model. BMC Cancer. 16: 797. [IF: 3.36; 63/322, Oncology]

55Kuo, C.Y.,† Lin, C.H.,# and Hsu, T. (2017) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling. Cancer Research. 77: 3406-3416. [9.12; 9/344, Oncology[ [This paper won the Ministry of Science and Technology, Taiwan, Outstanding Postdoctoral Research Paper Award, 2017].

56. Huang, H.-Y., Hsu, T. and Lin, B.F. (2017) gamma-Aminobutyric acid alleviates progression of renal inflammation and injury in the Vhlh gene-knockout mice: Tu-P14-28. Cytokine. 100: 185-186. [IF: 3.08; 107/446, Biochemistry]

57. Romani, P., Ignesti, M., Gargiulo, G., Hsu, T. (co-corresponding), and Cavaliere, V. (2018) Extracellular NME proteins: a player or a bystander? Lab. Invest. 98:248-257. [IF: 4.86; 16/128 Medicine, Research and Experimental]

58. Chen, H.Y., Hsiao, Y.T., Liu, S.C.,† Hsu, T.Woon, W.Y., and I, L. (2018) Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Physical Rev. Lett.121:018101. [IF: 8.84; 7/268, Physics and Astronomy]

 

59. Liu, S.C., Hsu, T., Chang, Y.S., Chung, A.K., Jiang, S.S,  OuYang, C.N., Hsueh, C., Liu, Y.P., Yuh, C.H., and Tsang, N.M. (2018) Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through YAP1-FAK/PXN signaling. Nature Communications. 9: 5105. [IF: 12.35; 3/64, Multidisciplinary Sciences]

 

60. Huang, H.-Y., Hsu, T., and Lin, B.F. (2019) Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury. J. Functional Food. 60: 103419. [IF: 3.78; 37/206; Medicine (miscellaneous)]

 

61. Mezzofanti, E., Ignesti, M., Hsu, T., Gargiulo, G., and Cavaliere, V. (2019) Vps28 is involved in the intracellular trafficking of Awd, the Drosophila homologue of NME1/2. Frontiers Physiol. 10: 983. [IF: 4.13; 47/167, Physiology]

 

62. Tseng, C.-H., Lin, C., Chang, H.-C., Liu, C.-C., Serafico, B.M.F., Wu, L.-C., Lin, C.-T., Hsu, T., Huang, C.-Y., and Lo, M.-T. (2019) A Real-World Implementation of Cloud-Based AI System for Large-Scale Arrhythmia ScreeningIEEE Computer. 52: 40-51. [IF: 3.56; 12/107; Computer Science, software engineering]

 

63. Hsu, T., Nguyen-Tran, Hieu-Huy #, and Trojanowska, M.E. (2019) Active roles of dysfunctional vascularendothelium in fibrosis and cancer. J. Biomed. Sci. 26: 86[Invited review] [IF: 5.20; 80/277, Cancer Research]

 

64. Nguyen-Tran, Hieu-Huy# and Hsu, T. (2020) Endothelial cell activation in the conditional Vhlh knockout kidney through oncostatin M pathwayCancer Immunol. Res. (3 Supplement)  A99-A99.

 

65. Nguyen, Thi-Ngoc# and Hsu, T. (2020) VHL inactivated kidney epithelial cells reprogram macrophage behavior through IL-6 and CXCL-1 secretion. Cancer Immunol. Res. (3 Supplement)  B92-B92.


研究計畫區

GRANT SUPPORT (since 2014)

Name of project

Role in project

Duration

Sponsoring agency

Brief description

Budget


Study of tissue inflammation and the initiation of renal cell carcinoma

Principle

investigator

Aug. 1, 2014-

July 31, 2017

Ministry of Science and Technology103-2320-B-008-002-MY3

Study the correlation between inflammation and cancer

NTD $1.48 mil/yr

(USD $48,000/yr)

Center for Preventive Biomedical Science and Engineering

Principle investigator

Jan.1, 2014 – 

Dec. 31, 2023

Taiwan Bio-Development Foundation (TBF)

Establish a research program on preventive medicine.

NTD $2.5 mil/yr

(USD $81,000/yr)

Study of the link between inflammation and carcinogenesis using a model of renal cell

carcinoma

Principle investigator

Jan.1, 2016 – 

Dec. 31, 2018

National Health Research Institute (NHRI EX105-0501BI)

 

Study the inflammatory process that leads to cancer formation

NTD $2.3 mil/yr

(USD $74,000/yr)

Study of crosstalk between hypoxic tumor cells and inflammatory

microenvironment

Principle investigator

Aug. 1, 2017-July 31, 2020

Ministry of Science and Technology MOST 106-2320-B-008-007-MY3

Study the cellular mechanism by which mutant epithelial cells induce inflammation

NTD $1.48 mil/yr

(USD $48,000/yr)

Analysis of kidney macrophage population at the single-cell level—marker discovery in kidney inflammation and cancer

 

Principle investigator

Aug. 1, 2017-July 31, 2020

Ministry of Science and Technology MOST 106-2321-B-008-001

Study of the immune cell repertoire during kidney inflammation and transition to cancer

NTD $10 mil/yr

(USD $323,000/yr)

The role of Cellular Metabolic Abnormality and ER Stress in the Initiation of Renal Cell Carcinoma 

 

Principle investigator

Jan.1, 2019 – 

Dec. 31, 2021

National Health Research Institute  (NHRI-EX108-10801BI)

Study the metabolic abnormalitiesthat lead to inflammation and cancer formation

NTD $2.8 mil/yr (USD $90,000/yr)


專利區