專任-系統生物與生物資訊組   首頁 師資介紹 專任-系統生物與生物資訊組
劉淑貞 助理教授 Shu-Chen Liu
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學經歷

Education:

2009   Ph.D.     國防醫學院/中央研究院/國家衛生研究院合辦,生命科學研究科所

2000   M.S.    國立陽明大學醫學工程暨技術學院,放射醫學科學研究所


Experience:

2016-present      Assistant professor

(Department of Biomedical Sciences and Engineering, National Central University)

2015-2016/01   Assistant research scholar

(Department of Biomedical Sciences and Engineering,National Central University)

2009-2015       Postdoctoral research fellow

(Molecular Medicine Research Center, Chang Gung University)

2001-2009       Ph.D. program

(Division of Molecular and Genomic Medicine, National Health Research Institutes)


Professional Memeberships:

2004-Present     Taiwan Society for Therapeutic Radiology and Oncology (台灣放射腫瘤學會)


實驗室研究主題 (Research Interests)
1.腫瘤微環境(Tumor microenvironment)
2.頭頸癌惡性化機轉(Molecular mechanisms of head and neck cancer)
3.癌組織單細胞基因體研究(Tumor single cell genomics)
4.腫瘤免疫學(Immuno-Oncology)

論文著作區

SCI期刊論文

Shu-Chen Liu*, Ngan-Ming Tsang, Po-Ju Lee, Yun-Hua Sui, Chen-Han Huang and Tzu-Tung Liu (2021, Apr). Epstein-Barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment. Cancer Research, 2021 Apr 6; doi: 10.1158/0008-5472.


Mai-Huong Thi Nguyen, Chen-Huan Lin, Szu-Mam Liu, Azusa Miyashita, Hironobu Ihn, Hsuan Lin, Chi Hou Ng, Jen-Chieh Tsai, Ming-Hong Chen ,Mu-Shiun Tsai, In-Yu Lin, Shu-Chen Liu, Long-Yuan Li, Satoshi Fukushima, Jean Lu, Nianhan Ma (2020, Dec). miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma. Neoplasia, 2020 Dec;22(12):789-799.


Zong-Lin Sie, Ruei-Yang Li, Bonifasius Putera Sampurna, Po-Jui Hsu, Shu-Chen Liu, Horng-Dar Wang, Chou-Long Huang, and Chiou-Hwa Yuh (2020, Mar). WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers, 12(3), 575.


Wen Ching Chuang, Ngan Ming Tsang, Chi Cheng Chuang, Kai Ping Chang,Ping Ching Pai, Kuan Hung Chen, Wen Chi Chou, Shiao Fwu Tai, Shu Chen Liu, Kin Fong Lei (2020, Jan). Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data. Plos one, 15(1):e0228360.


Shu-Chen Liu*. The molecular basis of LIF-mediated NPC metastasis. Cancer Research, 2019;79(13 Suppl).


Kuan-Hung Chen, Ngan-Ming Tsang, Wen-Chi Chou, Shiao Fwu Tai, Shu-Chen Liu, Kin-Fong Lei, Kai-Ping Chang, Wen-Ching Chuang, Ping-Ching Pai (2019, May). Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer. Journal of Geriatric Oncology, 2019 May 10. pii: S1879-4068(19)30040-2.


Shu-Chen Liu*, Tien Hsu , Yu-Sun Chang, An-Ko Chung, Shih Sheng Jiang, Chun-Nan OuYang, Chiou-Hwa Yuh, Chuen Hsueh, Ya-Ping Liu, Ngan-Ming Tsang*. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling. Nature communications, (2018) 9: 5105.


Ji-Lin Jou, Shu-Chen Liu and Lin I (2019, May). Tail shape evolution dynamics of MDCK cells on fibronectin substrates. Biomedical Physics & Engineering Express, 2019 (5) 045001.


Chen HY, Hsiao YT, Liu SC, Hsu T, Woon WY, and I L*. Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Physical Review Letters. 2018, 121(1): 01810.


Wu TS1, Wang LC1, Liu SC1, Hsu TY, Lin CY, Feng GJ, Chen JM, Liu HP, Chung IC, Yen TC, Chang YS, Liao SK, Chang C, Chow KP. EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model. J Immunol. 2015 May 1;194(9):4577-87 (1co-first author).


Hsu CW, Yu JS, Peng PH, Liu SC, Chang YS, Chang KP, Wu CC. Secretomic profiling of primary cells reveals that THBS2 is a salivar biomarker of oral cavity squamous cell carcinoma. J Proteome Res. 2014 Nov 7;13(11):4796-807.


Liu SC and Chang YS. Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis. Molecular & Cellular Oncology. 2014 Jul 15 1(1): e29900.


Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS*. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest. 2013 Dec 2;123(12):5269-83.


Liu HP, Chen CC, Wu CC, Huang YC, Liu SC, Liang Y, Chang KP, Chang YS.

Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 2012 May;8(5): e1002690.


Peng PH, Wu CC, Liu SC, Chang KP, Chen CD, Chang YT, Hsu CW, Chang YS, Yu JS. Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J Proteomics. 2011 May 1;74(5):744-57.  


Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res. 2009 Aug 1;69(15):6122-30.


Chen HC, Ma HI, Sytwu HK, Wang HW, Chen CC, Liu SC, Chen CH, Chen HK, Wang CH. Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. J Neurosci Res. 2010 Nov 15;88(15):3308-18.


Jiang SS, Chang IS, Huang LW, Chen PC, Wen CC, Liu SC, Chien LC, Lin CY,


Hsiung CA, Juang JL. Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus. J Virol. 2006 Sep; 80(18):8989-99.


Wen CC, Wu YJ, Huang YH, Chen WC, Liu SC, Jiang SS, Juang JL, Lin CY, Fang WT, Hsiung CA, Chang IS. A Bayes regression approach to array-CGH data. Stat Appl Genet Mol Biol. 2006;5: Article3.


會議論文

Lee PJ, Sui YH, Liu TT, Cai CH, Liu SC* (2020, Mar). EBV+-Nasopharyngeal Cancer-Derived Exosomes Regulate Function of Stromal Fibroblasts. EACR-AACR-ASPIC ‘Basic and Translational Research Conference Tumor Microenvironment, Lisbon, Portugal.


Liu SC*, Po-Ju Lee, Tzu-Tung Liu, Yun-Hua Sui, Ngan-Ming Tsang (2020, Mar). Interactions between Epstein-Barr virus and tumor-associated adipocytes . EACR-AACR-ASPIC ‘Basic and Translational Research Conference Tumor Microenvironment, Lisbon, Portugal. MOST 108-2314-B-008-002. 


Liu SC*, Lee PJ, Kao MZ, Liu TT, Sui YH, Tsang NM (2019, May). Epstein-Barr virus dedifferentiates adipocytes and modulates tumor microenvironment. 2019 The 24th Taiwan Joint Cancer Conference, Taipei, Taiwan.


Lee PJ and Liu SC*. SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14).


Kao MZ, Lee PJ, Chung MC, Chen CC* and Liu SC*. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14).


PJ and Liu SC*. The potential role of YAP1 protein in AZD0530-mediated suppression of human fibroblast activation (The 23rd Taiwan Joint Cancer Conference, 2018/5/5~6).


Kao MZ, Chung MC, Chen CC, Liu SC*. Magnet Halbach Arrays-Mediated Effects in Carcinoma Cells. (The 23rd Taiwan Joint Cancer Conference, 2018/5/5~6).


Liu SC*, Hsu T, Yuh CH, Tsang NM. Cytoplasmic LIF Reprograms Cancer Invasive Modes to Facilitate Metastasis and Enhance Multidrug Resistance. The 22nd Taiwan Joint Cancer Conference (2017, May). (優秀論文獎).


Liu SC*, Tsang NM, Hsu T, Chang YS (2016, Aug). Leukemia inhibitory factor drives invadopodia formation and genome instability. 2016 17th International Symposium on EBV and associated diseases (Zurich, Switzerland).


Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance (Oral presentation). 2014 Academic Conference of TASTRO & The 4th Annual Meeting of TAROS (Awards of The Cancer Prevention & Treatment Foundation). (優秀論文獎)


Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Poster presentation). 2014 16th International Symposium on EBV and Associated Diseases (Brisbane, Australia).


Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Oral & poster presentation). 2014 The 19th Taiwan Joint Cancer Conference. (優秀論文獎)


Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Chang YS. LIF regulates p70S6K to promote progressiveness and radioresistance of NPC (Poster presentation). EBV 50th Anniversary, 23rd - 25th March 2014, Keble College Oxford.


Liu SC. Functional monitoring of thrombin-induced responses in cancer cells (Oral presentation, invited speaker). xCELLigence Symposium 2010 Beijing, China.


Liu SC, YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. Ga12-dependent pathway promotes tumorigenesis and metastasis of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization (Oral presentation). 2009 Research Day, National Health Research Institutes, Taiwan.

研究計畫區
計畫
1. 科技部專題計畫(109-2314-B-008 -001 -MY3) (主持人)
2. 榮台聯大研究計畫(2019/1/1~2019/12/31): VGHUST108-G4-3-1 (主持人)。
3. 科技部專題計畫(Most 108-2314-B-008 -002 -)(主持人)。
4. 科技部專題計畫(Most 107-2314-B-008-003-)(主持人)。
5. 榮台聯大研究計畫(2018/1/1~2018/12/31): VGHUST107-G4-2-1 (主持人)。 
6. 國際科技人士短期訪問計畫(計畫編號:106WCSFA0700029)(國立中央大學生醫科學與工程學系主辦「2017 生物醫學工程科技研討會」暨「科技部醫學工程學門成果發表會」。
7. 榮台聯大研究計畫(2017/1/1~2017/12/31): VGHUST106-G4-2-1(主持人)。
8. 科技部延攬研究學者計畫(2015/08/01~2018/07/31(MOST -104-2321-B-008-003-MY3)(主持人)。


實驗室成員
研究生:邵瑋如,蔡承翰,李柏儒
生醫系大學部專題生: 劉子彤,隋昀華,李亦倫,李心慈,邱子筠,鄭涵勻,孫克文,陳璿仲

學生榮譽
李柏儒
--國際期刊共同作者 (Cancer Research, 2021 Apr 6; doi: 10.1158/0008-5472) 。
--109學年度第一學期中央大學優秀學生獎學金。
--日本熊本大學癌症生物實驗室實習(2020/3~2020/8) 。
--獲科技部研究生出席國際會議補助(109-2922-1-008-018): EACR-AACR-ASPIC ‘Basic and Translational Research Conference Tumor Microenvironment, Lisbon Portugal.
--2019斐陶斐榮譽學會會員。
--國立中央大學107學年度第一學期中央大學優秀學生獎學金。
--獲科技部107年度大專生研究計畫(計畫編號:107-2813-C-008-059-B) 。
--中研院生醫所暑期實習(2017/7~2017/9)。

隋昀華
--國際期刊共同作者 (Cancer Research, 2021 Apr 6; doi: 10.1158/0008-5472) 。
--2021 國立中央大學生醫理工學院 繪畫創作競賽 第二名。
--109學年度第一學期 中央大學優秀學生獎學金。
--109年度生醫系大學生專題研究成果報告比賽第二名。
--科技部109年度大專生研究計畫(計畫編號:109-2813-C-008-034-B) 。
--2020中央大學生醫理工學院繪畫創作比賽第三名。
--中研院生醫所暑期實習(2019/7~2019/9) 。
--2019(高雄醫學院主辦)醫材輔具健康福祉講座交流競賽佳作。
--2019中央大學生醫理工學院繪畫創作比賽第二名及佳作。
--國立中央大學108學年度第二學期中央大學優秀學生獎學金。
--108 生醫科學與工程學系第一學期書卷獎。
--108 生醫科學與工程學系第二學期書卷獎。
--2018(成功大學主辦)生技醫材設計與開發學分班&次世代醫療器材新創開發戰鬥營第二名。

劉子彤
--國際期刊共同作者 (Cancer Research, 2021 Apr 6; doi: 10.1158/0008-5472) 。
--109學年度第一學期 中央大學優秀學生獎學金。
--(2020)國家衛生研究院大專生成果報告評鑑”優選” 。
--109年度生醫系大學生專題研究成果報告比賽佳作。
--國家衛生研究院大專生研習計畫(2020/7) 。
--科技部109年度大專生研究計畫(計畫編號:109-2813-C-008-033-B) 。
--劉子彤:中研院生醫所暑期實習(2019/7~2019/9) 。
--劉子彤:2018中央大學全校運動會兩千五百公尺女子組第一名;八百公尺女子組第二名。


李心慈
--中研院生醫所暑期實習(2020/7~2020/9) 。


邱子筠
--中研院生醫所暑期實習(2020/7~2020/9) 。


學生會議論文發表
-- Yun-Hua Sui, Tzu-Tung Liu, Po-Ju Lee, Shu-Chen Liu*. LIF regulates macrophage immune response in NPC tumor microenvironment. (2021)第28屆細胞及分子生物新知研討會
--Tzu-Tung Liu, Yun-Hua Sui, Po-Ju Lee, Shu-Chen Liu*.Next-generation  sequencing-based analysis of NPC-derived exosomes in macrophage polarization and immune surveillance (2021)第28屆細胞及分子生物新知研討會.
--國際研討會論文Lee PJ, Sui YH, Liu TT, Cai CH, Liu SC* (2020, Mar). EBV+-Nasopharyngeal Cancer-Derived Exosomes Regulate Function of Stromal Fibroblasts. EACR-AACR-ASPIC ‘Basic and Translational Research Conference Tumor Microenvironment, Lisbon, Portugal.
--國際研討會論文. Lee PJ and Liu SC*. SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14). 
-- Lee PJ and Liu SC*. The potential role of YAP1 protein in AZD0530-mediated suppression of human fibroblast activation (2018/5/5~6). 第二十三屆台灣癌症聯合學術年會(The 23rd Taiwan Joint Cancer Conference).
--Lee PJ and Liu SC*. Yes-associated Protein 1 regulates activation of Cancer-associated Fibroblasts (2018/03/24~03/25). 第33屆生物醫學聯合學術年會(The 33th JACBS Conference)
--國際研討會論文.Ming-Ze Kao, Po-Ju Lee, Min-Che Chung, Chien-Chang Chen* and Shu-Chen Liu*. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14).
-- Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, Shu-Chen Liu*. Magnet Halbach Arrays-Mediated Effects in Carcinoma Cells (2018/5/5~6). 第二十三屆台灣癌症聯合學術年會 (The 23rd Taiwan Joint Cancer Conference).
-- Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, Shu-Chen Liu*. Magnet Halbah Arrays Induce Cell Cycle Redistribution of Cancer Cells (2018/03/24~03/25). 第33屆生物醫學聯合學術年會(The 33th JACBS Conference).
--Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, and Shu-Chen Liu. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells. 「2017生物醫學工程科技研討會」暨「科技部醫學工程學門成果發表會」

專利區
專利
1. Potentiation of nasopharyngeal cancer radiotherapy by inhibitors of leukemia inhibitory factor  (美國)( US9,194,872 B2; 專利期限2015/11 至2034/04)。
2. 評估癌症於治療後情況的方法及其相關應用 (中國)( CN 104623663 A; 專利期限2017 /7/14至2034/1/26) 
3. 鼻咽癌治療的醫藥  (台灣,發明第I486172,專利期間: 2015/06~2033/11)。

獎項
- 2017 The 22nd Taiwan Joint Cancer Conference Award 
-2014 Awards of The Cancer Prevention & Treatment Foundation
-2014 The 19th Taiwan Joint Cancer Conference Poster Award
-2011 NHRI Outstanding Paper Award 
-Awarded for excellent thesis in 2009 NHRI Research Day