專任-生物醫學工程(生醫材料與奈米醫學工程組)   首頁 師資介紹 專任-生物醫學工程(生醫材料與奈米醫學工程組)
李宇翔 教授 兼生醫理工學院 副院長 Yu-Hsiang Lee
從聘系所: 化學工程與材料工程學系
專線電話:03-4227151轉 27755
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學經歷

Education/Experience:

2019 -          :  Professor

2014-  2019 :  Associate Professor

2010 - 2014 :  Assistant Professor 

2008 - 2010 :  Postdoctoral Fellow, UCLA Dental Research Institute (CA, USA)

2006 - 2008 :  Research Scientist, Sierra Sciences LLC (NV, USA)

Research Interests:

[1] Biomaterials

[2] Nanomedicine/Drug Delivery

[3] Photobioreactor Engineering

[4] Mechanotransductional Biology

論文著作區

Selected Journal paper (*Corresponding author)

  1. Lee Y-H*, Chiu C-C, Chang C-Y. Engineered Photo-Chemical Therapeutic Nanocomposites Provide Effective Antibiofilm and Microbicidal Activities against Bacterial Infection in Porous Devices. Biomaterials Science (SCI) In press DOI: 10.1039/D0BM01814G
  2. Lee Y-H*, Hong Y-L, Wu T-L. Development of Chitosan-Based Composite Hydrogel Containing Silver Ions and Growth Factor-Loaded Nanoparticles with Improved Cell Proliferation and Sustainable Antimicrobial Property for Diabetic Wound Healing. Materials Science & Engineering C: Materials for Biological Applications 2021; 118: 111385. (SCI)
  3. Hsiao K-H, Huang C-M*, Lee Y-H*. Novel Rifampicin and Indocyanine Green Co-Loaded Perfluorocarbon Nanodroplets Provide Effective in vivo Photo-Chemo-Probiotic Antimicrobility against Pathogen of Acne Vulgaris Cutibacterium acnes. Nanomaterials 2020; 10(6): 1095. (SCI)
  4. Lee Y-H*, Sun J-H. Multifunctional Fluorocarbon Photobioreactor System: A Novel Integrated Device for CO2 Segregation, O2 Collection, and Enhancement of Microalgae Growth and Bioproductions. Bioprocess and Biosystems Engineering 2019; 42: 1591-1601. (SCI)
  5. Lee Y-H*, Tuyet P-T. Synthesis and Biological Evaluation of Quercetin-Zinc (II) Complex for Anticancer and Anti-Metastasis of Human Bladder Cancer Cells. In Vitro Cellular & Developmental Biology - Animal 2019; 55(6): 395-404. (SCI)
  6. Hsiao K-H, Huang C-M*, Lee Y-H*. Development of Rifampicin-Indocyanine Green-Loaded Perfluorocarbon Nanodroplets for Photo-Chemo-Probiotic Antimicrobial Therapy. Frontiers in Pharmacology 2018; 9: 1254.(SCI)
  7. Lee Y-H*, Lin Y-C. Anti-EGFR Indocyanine Green-Mitomycin C-loaded Perfluorocarbon Double Nanoemulsion: A Novel Nanostructure for Targeted Photochemotherapy of Bladder Cancer Cells. Nanomaterials 2018; 8: 283. (SCI)
  8. Lee Y-H*, Lai C-W, Cheng Y-C*. Fluid Shear Stress Induces Cell Cycle Arrest in Human Urinary Bladder Transitional Cell Carcinoma through Bone Morphogenetic Protein Receptor-Smad1/5 Pathway. Cellular and Molecular Bioengineering 2018; 11: 185-195. (SCI)
  9. Lee Y-H*, Weng T-C. Development of Synthetic Perfluorinated Photobioreactor System for Simultaneous Carbon Dioxide Separation and Promotion of Microalgae Growth and Productions. Journal of Chemical Technology and Biotechnology 2018; 93: 1065-1074. (SCI)
  10. Lee Y-H*, Yeh C-H. Laminar Shear Stress Inhibits High Glucose-Induced Migration and Invasion in Human Bladder Cancer Cells. In Vitro Cellular & Developmental Biology - Animal 2018; 54: 120-128. (SCI)
  11. Lee Y-H*, Ma Y-T. Synthesis, Characterization, and Biological Verification of Anti-HER2 Indocyanine Green-Doxorubicin-Loaded Polyethyleneimine-Coated Perfluorocarbon Double Nanoemulsions for Targeted Photochemotherapy of Breast Cancer Cells. Journal of Nanobiotechnology 2017; 15(1): 41 (SCI)
  12. Lee Y-H*, Chang D-S. Fabrication, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Doxorubicin-Encapsulated PEG-b-PLGA Copolymeric Nanoparticles for Targeted Photochemotherapy of Breast Cancer Cells. Scientific Reports 2017; 7: 46688 (SCI)
  13. Lee Y-H*, Li P-H. Using Resonant Ultrasound Field-Incorporated Dynamic Photobioreactor System to Enhance Medium Replacement Process for Concentrated Microalgae Cultivation in Continuous Mode. Chemical Engineering Research and Design 2017; 118(2017): 112-120 (SCI).
  14. Lee Y-H*, Lai Y-H. Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells. PLOS ONE 2016; 11(12): e0168192 (SCI)
  15. Lee Y-H*, Lee C-C, Huang C-H, and Ho F-M*. Laminar Shear Stress Promotes Nicotine-Induced Inflammation and Hemostatic Expression in Human Endothelial Cells. Cellular and Molecular Bioengineering 2016; 9(3): 466-477 (SCI)
  16. Lee Y-H*, Lai Y-H. Fabrication and Characterization of HER2 Cell Receptor-Targeted Indocyanine Green-Encapsulated Poly(Lactic-co-Glycolic Acid) Nanoparticles. Peertechz Journal of Biomedical Engineering 2015; 1(1): 015-020.
  17. Lee Y-H, Chen R-S, Chang N-C, Lee K-R, Huang C-T, Huang Y-C, and Ho F-M*. Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells. Annals of Biomedical Engineering 2015; 43(9): 2220-2230. (SCI)
  18. Lee Y-H*, Wu Z-Y. Enhancing Macrophage Drug Delivery Efficiency via Co-Localization of Cells and Drug-Loaded Microcarriers in 3D Resonant Ultrasound Field. PLOS ONE 2015; 10(8): e0135321. (SCI)
  19. Lee Y-H*, Yeh Y-L. Reduction of Oxygen Inhibition Effect for Microalgal Growth Using Fluoroalkylated Methoxy Polyethylene Glycol-Stabilized Perfluorocarbon Nano-Oxygen Carriers. Process Biochemistry 2015; 50(7): 1119-1127. (SCI)
  20. Lee Y-H*, Yeh Y-L. Using Polyethylene Glycol as Nonionic Osmoticum to Promote Growth and Lipid Production of Marine Microalgae Nannochloropsis oculataBioprocess and Biosystems Engineering 2014; 37(8): 1669-1677. (SCI)
  21. Lee Y-H*, Yeh Y-L, Lin K-H, and Hsu Y-C. Using Fluorochemical as Oxygen Carrier to Enhance the Growth of Marine Microalga Nannochloropsis oculata. Bioprocess and Biosystems Engineering 2013; 36(8): 1071-1078. (SCI)
  22. Lee Y-H*, Tseng C-S, and Wei Y-L. Fabrication and Characterization of CdSe/ZnS Quantum Dots-Doped Polystyrene Microspheres Prepared by Self-Assembly. Journal of Materials Research 2012; 27(22): 2829-2836. (SCI)
  23. Lee Y-H, Joshipura K, Vergara JL, and Wong DT*. Detection of Type II Diabetes Mellitus Using Salivary Transcriptomic Biomarkers. Genomic Medicine, Biomarkers and Health Sciences 2012; 4: 7-11. (SCOPUS)
  24. Lee Y-H, Kim JH, Zhou H, Kim BW, Wong DT*. Salivary Transcriptomic Biomarkers for Detection of Ovarian Cancer: For Serous Papillary Adenocarcinoma. Journal of Molecular Medicine 2012; 90(4): 427-434. (SCI) 
  25. Lee Y-H, Zhou H, Reiss JK, Yan X, Zhang L, Chia D, and Wong DTW*. Direct Saliva Transcriptome Analysis. Clinical Chemistry 2011; 57(9): 1295-1302. (SCI)
  26. Lee Y-H, Peng C-A*. Effect of hypotonic stress on retroviral transduction. Biochemical and Biophysical Research Communications 2009; 390(4) 1367-1371. (SCI)
  27. Lee Y-H, Wong DT*. Saliva: An emerging biofluid for early detection of diseases. American Journal of Dentistry 2009; 22(4): 241-248. (SCI)
  28. Lee Y-H, Peng C-A*. Nonviral Transfection of Suspension Cells in Ultrasound Standing WaveFields. Ultrasound in Medicine and Biology 2007; 33(5): 734-742. (SCI)
  29. Lee Y-H, Lai C-Y, Li P-C, Peng C-A*. Ultrasound-Mediated Perfluorocarbon Microbubbles Bursting for Gene Transfection. Journal of Medical and Biological Engineering 2005; 25(4): 153-158. (SCI).
  30. Lee Y-H, You J-O, Peng C-A*. Retroviral transduction of adherent cells in resonant acoustic fields. Biotechnology Progress 2005; 21(2): 372-376. (SCI)
  31. Lee Y-H, Peng C-A*. Enhanced retroviral gene delivery in ultrasonic standing wave fields.Gene Therapy 2005; 12(7): 625-633. (SCI)
研究計畫區


專利區

[1] 李宇翔,葉昱伶。培養擬球藻之系統。中華民國專利 發明第I 487481號。(2015-2033)

[2] 宇翔,馬韻婷。藥物丸粒、其醫藥組合物及其用途。中華民國專利 發明第I 684464號。(2020-2036)