專任教師-系統生物與生物資訊組   首頁 師資介紹 專任教師-系統生物與生物資訊組
徐 沺 生醫講座教授兼生醫理工學院院長 Tien Hsu
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專線電話:03-4227151轉36115
傳真電話:
E-mail :tienhsu@ncu.edu.tw
學經歷

Curriculum Vitae

 

Bachelor, Department of Agricultural Chemistry, National Taiwan University, 1977-1981

PhD, Medical University of South Carolina, USA, 1983-1988

Postdoc, Department of Cellular and Developmental Biology, Harvard University, USA, 1989-1993

Assistant Professor – Professor, Hollings Cancer Center, USA, 1993-2009

Professor of Medicine, Boston University School of Medicine, 2009-2013

Professor of Systems Biology and Bioinformatics, National Central University, Taiwan, 2013-present

Dean, College of Heath Sciences and Technology, National Central University, Taiwan, 2014-present

論文著作區

Publications

Papers (since 2005):
(Hsu lab members in bold: undergraduate students¶; graduate students#; postdocs†)


  1. Cavaliere, V., Donati, A., Hsouna, A.†, Hsu, T. and Gargiulo, G. (2005) The dAkt kinase controls follicle cell size during Drosophila oogenesis. Developmental Dynamics 232: 845-854.

  2. Adereth, Y.#, Champion, K. J.#, Hsu, T. and Vincent Dammai (2005) Site-directed mutagenesis using Pfu-DNA polymerase and T4-DNA ligase. BioTechniques 38: 864, 866, 868.

  3. Pei, H., Li, C., Adereth, Y.#, Hsu, T., Watson, D.K. and Li, R. (2005) Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Research 65: 7205-7213.

  4. Adereth, Y.#, Dammai, V., Kose, N., Li, R. and Hsu, T. (2005) RNA-dependent integrin 3 protein localisation regulated by the Muscleblind-like protein MLP1, Nature Cell Biology 7: 1240-1247 [Accompanied by News and Views Nature Cell Biology 7: 1155-1156] [Highlighted in Nature Cell Migration Gateway, Dec. 2005]


  5. Arquier, N., Vigne, P., Duplan, E., Hsu, T., Therond, P.P., Frelin, C. and D'Angelo, G. (2006) Analysis of the hypoxia-sensing pathway in Drosophila melanogaster. Biochem. J., 393: 471-480.


  6. Hsu, T. (co-corresponding author), Adereth, Y.†, Kose, N. and Dammai, V. (2006) Endocytic function of Von Hippel-Lindau tumor suppressor protein regulates surface localization of FGF receptor 1 and cell motility. J. Biol. Chem. 281: 12069-12080. [Editor's Choice, Cancer, Science's STKE, May 2006]


  7. Hsouna, A.†, Lawal, H.O., Izevbaye, I. and Hsu, T. (co-corresponding author) and O'Donnell, J.M. (2007) Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev. Biol. 308: 30-43.


  8. Nallamothu, G.†, Woolworth, J.A.#, Dammai, V. and Hsu, T. (2008) awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Mol. Cell. Biol. 28: 1964–1973.


  9. Chintalapudi, M. R.†, Markiewicz, M., Kose, N, Dammai, V., Championl, K.J.#, Hoda, R. S., Trojanowska, M. and Hsu, T. (2008) Cyr61/CCN1 and CTGF/CCN2 mediate the pro-angiogenic activity of VHL mutant renal carcinoma cells. Carcinogenesis 29: 696-703.


  10. Champion, K.J.#, Guinea, M.†, Dammai, V. and Hsu, T. (2008) Endothelial function of von Hippel-Lindau tumor suppressor gene: control of FGF receptor signaling. Cancer Research 68: 4649-4657.


  11. Bu, S., Kapanadze, B., Hsu, T. and Trojanowska, M. (2008) Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on TGFbeta/Smad pathway are mediated through the PTEN/PPM1A dependent pathway. J. Biol. Chem. 283:19593-19602.


  12. Mahajan, S., Dammai, V., Hsu. T. and Kraft, A.S. (2008) Hypoxia-inducible factor-2 regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 29: 1734-1741.

  13. Nallamothu, G.†, Dammai, V. and Hsu, T. (2009) Developmental Function of Nm23/awd - A Mediator of Endocytosis. Mol. Cell. Biochm. 329: 35-44. [Review]

  14. Woolworth, J.A.#, Nallamothu, G.†, and Hsu, T. (2009) The Drosophila metastasis suppressor Nm23 homolog, awd, regulates epithelial integrity during oogenesis. Mol. Cell. Biol. 29: 4679-4690. [Selected for cover photo]

  15. Duchi, S.#, Fagnocchi, L., Cavaliere, V., Hsouna, A.†, Gargiulo, G. and Hsu, T. (2010) Drosophila VHL tumor suppressor gene regulates epithelial morphogenesis by promoting microtubule stability. Development 137:1493-1503. [Featured "In This Issue"]

  16. Hsouna, A.†, Kose, N., Guinea, M.†, Dammai, V. and Hsu, T. (2010) Drosophila von Hippel-Lindau tumor suppressor gene regulates epithelial tubule migration and lumen formation by promoting endocytosis. Mol. Cell. Biol. 30:3779-3794. [Featured in "Spotlight"][Selected for cover photo]

  17. Hsu, T. (2011) NME Genes in Epithelial Morphogenesis. Naunyn-Schmiedeberg Arch. Pharm. 384: 363-372. [Review]

  18. Liby, T.A., Spyropoulos, P., Lindner, H.B., Eldridge, J., Beeson, C., Hsu, T. and Muise-Helmericks, R.C. (2012) Akt3 Controls VEGF secretion and angiogenesis in ovarian cancer cells. Int. J. Cancer. 130: 532-543.

  19. Hsu, T. (2012) Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: Insights from model organisms. Oncogene 31: 2247-2257. [Invited Review]

  20. Bader, H. L.† and Hsu, T. (2012) Systemic VHL gene functions and the VHL disease. FEBS Lett. 586:1562-1569. [Invited Review]

  21. Ignesti, M., Barraco, M., Nallamothu, G.†, Woolworth, J.A.#, Duchi, S., Gargiulo, G., Cavaliere, V. and Hsu, T. (2014) abnormal wing discs regulates Notch signaling in Drosophila. BMC Biology. 12:12.

  22. Lin, C.H.#, Dammai, V. Adryan, B. and Hsu, T. (2014) Interaction between Nm23 and the tumor supressor VHL. Naunyn-Schmiedeberg Arch. Pharm. Jun 12. [Epub ahead of print]

  23. Pritchett, T.L.†, Bader, H.L.†, Henderson, J. and Hsu, T. (2014) Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory, and fibrotic lesions in the kidney. Oncogene, Jul 14;0. doi: 10.1038/onc.2014.197.

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