專任教師-生物醫學工程組   首頁 師資介紹 專任教師-生物醫學工程組
黃俊銘 生醫講座教授兼系主任 Eric Chun-Ming Huang
從聘系所:
專線電話:03-4227151轉36101
傳真電話:03-4253427
學經歷
學 歷:
國立台灣大學動物學系 (學士)(1990)
國立台灣大學生化分生所 (博士)(1995)
經 歷:
Fred Hutchinson Cancer Research Center, Seattle, Washington (博士後研究)(1995-1996)
Institute of Biomedical Sciences, Academia Sinica, Taipei (博士後研究)(1996-1998)
Institute of Biological Chemistry, Academia Sinica, Taipei (博士後研究)(1998-2000)
Assistant Professor, Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan (2000-2001)
Research Scientist, Vaxin, Inc., Birmingham, Alabama (2001-2002)
Assistant Professor, Department of Dermatology, The University of Alabama at Birmingham, Birmingham, Alabama (2002-2005)
Assistant Professor. Co-appointment, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama (2004-2005)
Co-director, Skin Proteomics Core of UAB Skin Disease Research Center (2004-2005)
Associate Professor, La Jolla Institute for Molecular Medicine, San Diego, California (2005-2007)
Research Scientist, Co-appointment, Veterans Medical Research Foundation of San Diego (2006-2009)
Associate Member, Moores Cancer Center, University of California, San Diego (2007-present)
Associate Professor, Division of Dermatology, School of Medicine, University of California, San Diego, CA (2006-2011)
Visiting Professor, Institutes of Biomedical Sciences &Shanghai Public Health Clinical Center, Fudan University (2013-present)
Professor, Division of Dermatology, School of Medicine, University of California, San Diego, CA (2011-present)
論文著作區
  1. * Shu, M, Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R.L., and Huang, C.-M. Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics Against Methicillin-Resistant Staphylococcus aureus. PLoS ONE, 2013;8(2):e55380
  2. Pornpattananangkul, D., Fu, V., Thamphiwatana, S., Zhang, L., Chen, M., Vecchio, J., Gao, W., Huang, C.-M., and Zhang, L. In Vivo Treatment of Propionibacterium acnes Infection with Liposomal Lauric Acids. Adv Healthcare Mater, 2013 Mar 12. doi: 10.1002/adhm.201300002. [Epub ahead of print]
  3. * Liu, P.F., Shu, C.W., and Huang, C.-M. Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein of Fusobacteria nucleatum. Curr Mol Med. 2013, in press.
  4. * Shu, M., Kuo, S., Wang, Y., Jiang, Y., Liu, Y.T., Gallo, R.L., and Huang, C.-M. Porphyrin Metabolisms in Human Skin Commensal Propionibacterium acnes Bacteria: Potential Application to Monitor Human Radiation Risk. Curr Med Chem. 2013;20(4):562-8.
  5. * Wang, Y., Zhu, W., Shu, M., Jiang, Y., Gallo, R.L., and Huang, C.-M. The Response of Human Skin Commensal Bacteria as a Reflection of UV Radiation: UV-B Decreases Porphyrin Production. PLoS ONE, 2012;7(10):e47798.
  6. * Shu, C.W., Liu, P.F., and Huang, C.-M. High-Throughput Screening for Drug Discovery of Autophagy Modulators. Comb Chem High Throughput Screen. 2012 Nov 1;15(9):721-9.
  7. * Zhu, W., Gallo, R.L., and Huang, C.-M. Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry. JoVE, 2012 Aug 7;(66).
  8. * Liu, P.F., Nakatsuji, T., Zhu, W., Gallo, R.L., and Huang, C.-M. Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine. 2011 Apr 12;29(17):3230-8.
  9. * Nakatsuji, T., Tang, D.C., Zhang, L., Gallo, R.L., and Huang, C.-M. Propionibacterium acnes CAMP Factor and Host Acid Sphingomyelinase Contribute to Bacterial Virulence:Potential Targets for Inflammatory Acne Treatment. PLoS ONE, 2011 Apr 12;6(4):e14797.
  10. * Chen, C.H., Wang, Y., Liu, Y.T., Zouboulis, C.C., Gallo, R.L., Zhang, L., Hsieh, M.F., and and Huang, C.-M. An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine. J Microbiol Biotechnol. 2011 Apr;21(4):391-9.
  11. Pornpattananangkul, D., Zhang, L., Olson, S., Aryal, S., Obonyo, M., Vecchio, K., Huang, C.-M., and Zhang, L. Bacterial Toxin-Triggered Drug Release from Gold Nanoparticle-Stabilized Liposomes for the Treatment of Bacterial Infection. J Am Chem Soc. 2011 Mar 23;133(11):4132-9.
  12. Chen, C.H., Huang, C.-M., and Hsieh, M.F. Enhancement of Catechin Skin Permeation via a Newly Fabricated mPEG-PCL-graft-2-hydroxycellulose membrane. J Memb Sci., 2011, 371:7.
  13. * Huang, C.-M., Chen, C.H., Pornpattananangkul, D., Zhang, L., Chan, M., Hsieh, M.F., and Zhang, L. Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids. Biomaterials. 2011, 32(1):214-221.
  14. * Lo, C. W., Lai, Y.K., Liu, Y.T., GalloR.L. and Huang, C.-M. Staphylococcus aureus hijacks a skin commensal to intensify its virulence: Immunization targeting β-hemolysin and CAMP factor. J. Investigative Dermatology, 2011, 131(2):401-9.
  15. * Chen, C.H., Zhang, X.Q., Lo, C.W., Liu, P.F., Liu, Y.T., Gallo, R.L., Hsieh, M.F., Schooley, R.T., and Huang, C-M. Proteomics validates the essentiality of alpha-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza A virus. Proteomics, 2010, 10(12):2396-401.
  16. * Yen, T., and Huang, C-M. Current status of acne vaccines. Expert Review of Dermatology, 2010, 5(5):561-566.
  17. Pornpattananangkul, D., Olson, S., Aryal, S., Sartor, M., Huang, C.-M., Vecchio, K., Zhang, L. Stimuli-Responsive Liposome Fusion Mediated by Gold Nanoparticles. ACS Nano. 2010, 27;4(4):1935-42.
  18. * Pan, T.L., Wang, P.W., Lee, W.R., Fang, C.L., Chen, C.C., Huang, C.-M., Fang, J.Y. Systematic evaluations of skin damage irradiated by an erbium:YAG laser: histopathologic analysis, proteomic profiles, and cellular response. J Dermatol Sci. 2010, 58(1):8-18.
  19. * Liu, P.F., Shi, W., Zhu, W., Smith, J.W., Hsieh, S.L., Gallo, R.L., and Huang, C.-M. Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. Vaccine, 2010, 28(19):3496-505.
  20. Chan, A. S., Chen, C.H., Huang, C.-M, Hsieh MF. Regulation of particle morphology of pH-dependent poly(epsilon-caprolactone)-poly(gamma-glutamic acid) micellar nanoparticles to combat breast cancer cells. J Nanosci Nanotechnol. 2010, 10(10):6283-97.
  21. * Yang, D., Pornpattananangkul, D., Nakatsuji, T., Chan, M., Carson, D., Huang, C.-M., Zhang, L. The Antimicrobial Activity of Liposomal Lauric Acids Against Propionibacterium acnes, Biomaterials, 2009, 30(30); 6035-6040. *share corresponding authorship
  22. * Nakatsuji, T., Kao, M.C., Zhang, L., Zouboulis, C.C., Gallo, R.L., and Huang, C.-M. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating β-defensin-2 expression. J. Investigative Dermatology, 2009, 130(4):985-94.
  23. Lai, Y., Nardo, A.D., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A.L., Wu, Z.R., Hooper, L.V., von Aulock, S., Radek, K.A., Huang, C.-M., Ryan, A.F., and Gallo, R.L. Commensal bacteria regulate TLR3-dependent inflammation following skin injury. Nature Medicine, 2009, 15(12):1377-82.
  24. ** Liu, P.F., Lo, C.W. Chen, C.H., Hsien, M.F., and Huang, C.-M. Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections. Curr Drug Metab., 2009, 10(8):875-84.
  25. * Nakatsuji, T., Kao, M.C., Fang, J.Y., Zouboulis, C.C., Zhang, L., Gallo, R.L., and Huang, C.-M. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J. Investigative Dermatology, 2009, 129(10):2480-8.
  26. * Zhang L, Pornpattananangku D, Hu CM, Huang, C.-M. Development of Nanoparticles for Antimicrobial Drug Delivery. Curr Med Chem. 2009, 17(6):585-94.
  27. Lee, D.Y., Huang, C.-M., Nakatsuji, T., Thiboutot D., Monestier, M., Kang, S.A., Gallo, R.L. Histone H4 is a major component of the antimicrobial action of human sebocytes. J. Investigative Dermatology, 2009,129(10):2489-96.
  28. ** Kao, M.C. and Huang, C. -M. Acne vaccines targeting Propionibacterium acnes. Giornaleital. Dermat. Venereol. 2009, 144(6):639-43.
  29. * Liu, P.F., Kinder Haake, S., Gallo, R.L., and Huang, C.-M. A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis. Vaccine, 2009, 27(10):1589-1595.
  30. Pan, T.L., Wang, P.W., Huang, C.-M., Chen, C.C., and Fang, J.Y. Elucidation of percutaneous absorption of chromium compounds by functional proteomic. Proteomics, 2009, 9(22):5120-31..
  31. Yusuf, N, Nasti, T.H., Huang, C. -M, Huber, B.S., Jaleel, T., Lin, H.Y., Xu, H., and Elmets, C.A. Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. J. Immunol. 2009,182(1):675-83.
  32. * Huang, C.-M. Smith, J.W., and Zhu, W. Mass Spectrometry-Based Label-Free Quantitative Proteomics, J. of Biomedicine and Biotechnology. 2010, 2010:840518.
  33. * Cuong NV, Hsieh MF, Huang, C.-M. Recent Development in Nano-sized Dosage Forms of Plant Alkaloid Camptothecin-Derived Drugs. Recent Pat Anticancer Drug Discov. 2009, 4(3):254-61.
  34. * Liu, P.F., Zhu, W., and Huang, C. -M. Vaccines and photodynamic therapies for oral microbial-related diseases. Curr Drug Metab., 2009, 10(1):90-93. PMID:19149517
  35. * Huang, C. -M. and Zhu, W. Profiling Human Saliva Endogenous Peptidome via a High-throughput MALDI-TOF-TOF Mass Spectrometry. Comb. Chem. High Throughput Screen, 2009, 12(5):521-31.
  36. * Nakatsuji, T., Rasochova, L., and Huang, C. -M. Vaccine therapy for P. acnes-associated diseases. Infect Disord Drug Targets., 2008, 8(3):160-165. PMID: 18782033
  37. * Huang, C. -M. Metabolism of drugs targeting microbiome. Curr Drug Metab., 2009, 10(1):1.
  38. * Nakatsuji, T., Shi, Y., Zhu, W., Huang, C.P., Chen, Y.R., Lee, D.Y., Smith, J.W., Gallo, R.L., and Huang, C. -M. Bioengineering a Humanized Acne Microenvironment Model: Proteomics Analysis of Host Responses to P. acnes Infection In Vivo. Proteomics, 2008, 8(16):3406-3415.
  39. * Nakatsuji, T., Liu, Y.T., Huang, C.P., Gallo, R.L., and Huang, C. -M. Antibodies Elicited by Inactivated P. acnes-based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris. J. Investigative Dermatology, 2008, 128(10):2451-2457. PMID: 18463682
  40. * Nakatsuji, T., Liu, Y.T., Huang, C.P., Gallo, R.L., and Huang, C. -M. Vaccination targeting a surface sialidase of P. acnes: Implication for new treatment of acne vulgaris. PLoS ONE, 2008, 3(2): e1551. PMID: 18253498
  41. * Huang, C.P., Liu, Y.T., Nakatsuji, T., Shi, Y., Gallo, R.L., Lin, S.B., and Huang, C. -M. Proteomics integrated with vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes. Proteomics Clin. Appl. 2008, 2(9): 1234-1245.
  42. ** Huang, C. -M, et. al. A Peptide with ProGln C-terminus in the Human Saliva Peptidome Exerts Bactericidal Activity Against Propionibacterium acnes. Antimicrob Agents Chemother., 2008, 52(5):1834-1836.
  43. * Fang, J. Y., Liu, P. F., and Huang, C. -M. Decreasing systemic toxicity by via transdermal delivery of anticancer drugs. Curr Drug Metab., 2008, 9(7):592-597.
  44. * Chen, S.T., et. al. and Huang, C.-M. Breast cancer microenvironment: Proteomics highlights the treatments targeting secretome. J. Proteome Res., 2008, 7(4):1379-1387. PMID: 18290608
  45. ** Huang, C. -M., et. al. In vivo tumor secretion probing via ultrafiltration and tissue chamber: Implication for anti-cancer drugs targeting secretome. Recent Patents Anticancer Drug Discov. 2008, 3 (1):48-54. PMID: 18289123
  46. * Lee, W.R., et. al. Huang, C.-M., and Fang, J.Y. Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control Release, 2008, 24;128(3):200-8. PMID: 18471920
  47. * Liu, Y.-T., Lin, S.-B., Huang, C.-P., and Huang, C. -M. A Novel Immunogenic Spore Coat-Associated Protein in Bacillus Anthracis: Characterization via Proteomics Approaches and a Vector-Based Vaccine System. Protein Expr Purif., 2008, 57(1):72-80. PMID: 18029197
  48. ** Shu, C.-W., and Huang, C.-M. HSP70s: from tumor transformation to cancer therapy. Clin. Med.: Oncol. 2008, 2:335-345.
  49. * Shi, Y., et al. and Huang, C.-M. Quantitative proteomes and in vivo secretomes of progressive and regressive UV-induced fibrosarcoma tumor cells: Mimicking tumor microenvironment using a dermis-based cell-trapped system linked to tissue chamber. Proteomics. 2007, 7(24):4589-4600.
  50. ** Nakatsuji, T., and Huang, C. -M. Potential Targets of P. acnes for New Treatments of P. acnes -Associated Diseases. Current Proteomics, 2007, 4(3):157-161.
  51. ** Huang, C. -M. Topical vaccination: the skin as a unique portal to adaptive immune responses. Springer Semin Immunopathol., 2007, 29(1):71-80. PMID: 17621956
  52. ** Huang, C. -M. In vivo secretome sampling technology for proteomics. Proteomics Clin. Appl. 2007, 1(9):953-962.
  53. ** Yang, S., Huang, C.-M. Recent advances in protein profiling of tissues and tissue fluids. Expert Rev Proteomics. 2007, 4(4):515-529. PMID: 17705709
  54. ** Liu, Y. -T., Huang, C. -M. In Vivo Sampling of Extracellular {beta}-Thymosin by Ultrafiltration Probes. Ann N Y Acad Sci. 2007, 12:104-113. PMID: 17495246
  55. * Huang, C. -M., Ananthaswamy, HN., Barnes, S., Ma, Y., Kawai, M., and Elmets, CA. Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses. Proteomics, 2006, 6(22):6107-6116. PMID: 17051643
  56. * Huang, C. -M., Wang, C.-C., Barnes, S., and Elmets, CA. In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics, 2006, 6(21):5805-5814. PMID: 17001601
  57. * Huang, C. -M., Wang, C.-C., Kawai, M., Barnes, S., and Elmets, CA. Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics. Mol Cell Proteomics. 2006, 5(3):523-532.
  58. * Huang, C. -M., Wang, C.-C., Kawai, M., Barnes, S., and Elmets, CA. In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics. J. Chromatography A., 2006, 109(2):144-151. PMID: 16376900
  59. ** Huang, C. -M., et. al. Proteomic characterization of skin and epidermis in response to environmental agents, Expert Rev. Proteomics, 2005, 2(5):809-820. PMID: 16209658
  60. * Huang, C. -M., et. al. A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen, Proteomics, 2005, 5(4):1013-1023.
  61. ** Huang, C,-M., et. al. Prospective highlights of functional skin proteomics. Mass Spectrometry Review 2005, 25(5): 647-660.
  62. ** Huang, C. -M., Elmets, CA., Tang, D. -C., Li, F., and Yusuf, N. Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs. Genomics, Proteomics, Bioinformatics. 2004, 2(3):143-151.
  63. * Huang, C.-M. Comparative proteomics analysis of human whole saliva. Archives of Oral Biology, 2004; 49(12) 951-962.
  64. * Huang, C.-M., Foster, KW., DeSilva TS, Van Kampen, KR, Elmets, CA and Tang DC. 2004. Identification of Bacillus anthracis proteins associated with germination and early outgrowth by proteomic profiling of anthrax spores. Proteomics, 2004, 4(9):2653-2661. PMID: 15352240
  65. Wu, YT., Jiaang, WT., Lin, KG., Huang, C.-M., et. al. A new N-acetylgalactosamine containing peptide as a targeting vehicle for mammalian hepatocytes via asialoglycoprotein receptor endocytosis. Curr Drug Deliv. 2004, 1(2):119-127.
  66. * Huang, C. -M., et. al. Comparative proteomic profiling of murine skin. J. Investigative Dermatology, 2003; 121(1):54-64.
  67. Huang, Y.-H, Chang, A.-Y, Huang, C.-M, et. al. Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells. Proteomics, 2002; 2(9): 1220-1228.
  68. * Chen, S.-T., Pan, T.-L., Tsai, Y.-C. and Huang, C.-M. Proteomics reveals protein profile changes in doxorubicin-treated MCF-7 human breast cancer cells. Cancer Letters, 2002; 181: 95-107.
  69. Huang, C.-M., et. al. Proteomics analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-KDa chromogranin B-derived fragment during neuronal differentiation. Molecular Brain Research, 2001; 92: 181- 192.
  70. Chang, A. Y.-M., Huang, C.-M., et. al. Involvement of noradrenergic innervation from Locus Coeruleus to hippocampal formation in negative feedback regulation of penile erection in the rat. Hippocampus, 2001; 11(6): 783-792. PMID: 11811673
  71. Chang, A. et. al., Huang, C.-M., and Chan, S.H.-H. Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat. J. Biomed. Sci., 2001; 8: 475-483. PMID: 11702011
  72. Pan T.-L, Goto S, Lord R, Huang Y.-C, Huang C.-M, Wang P.-W, et al., Proteome analysis in liver transplantation.Transplant Proc. 2001,33(1-2):156. PMID: 11266756
  73. Huang, C.-M., et. al. Specific delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis. Chemistry & Biology, 2000; 7:453-467. PMID: 10903942
  74. Chu, P.-W., Yap, M.-N., Huang, C.-M., et al. A proteomic analysis of secreted proteins from xylan-induced Bacillus sp. Strain K-1. Electrophoresis, 2000; 21:1740-1745.
  75. Huang , C.-M., and Kao, L-S. Nerve growth factor, epidermal growth factor and insulin differentially potentiate ATP-induced [Ca2+]i rise and dopamine secretion in PC12 cells. J. Neurochemistry, 1996; 66:124- 130. PMID: 8522943
  76. Huang, C.-M., Tsay, K-E., and Kao, L.-S. Role of Ca2+ in differentiation mediated by nerve growth factor and dibutyryl cyclic AMP in PC 12 cells. J. Neurochemistry, 1996; 67:530-539. PMID: 8764577 ** INVITED REVIEW; * CORRESPONDING AUTHOR
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