專任教師-生物醫學工程組   首頁 師資介紹 專任教師-生物醫學工程組
林澂 助理教授 Chen Lin
從聘系所:
專線電話:03-4227151轉27756
傳真電話:
E-mail :clin@ncu.edu.tw
學經歷

Education

National Central University, Taiwan

Ph.D. in Institute of Systems Biology and Bioinformatics

September, 2008 ~ July, 2012

National Yang Ming University, Taiwan

M.S.of Institute of Physiology

September, 2002 ~ June, 2004


Dissertation

 

Ph.D. Degree

Title: “Application of Hilbert-Huang Transform in Exploring the Nonlinear Characteristics of Biomedical Signals”

Advisor: Prof. Norden Er Huang

 

M.S. Degree

Title: ”Short-term and long-term outcome assessment in surgical critically-ill patients-linear and nonlinear analyses of heart rate dynamics”

Advisor: Prof. Yu Ru Kou

 

 

Academic and professional experiences

Assistant Professor

Department of Biomedical Sciences and Engineering, National Central University

Aug, 2015~

Assistant Research Fellow

Center for Adaptive Data Analysis, National Central University

Feb, 2014~Jul, 2015

Taiwanese Team of Qualcomm Tricorder XPRIZE Competition (Co-PI in Vital Sign Group)

Sep, 2013~April, 2017

Post-Doctoral Fellow

Department of Behavioral Science and Psychiatry, Stanford University

Sep, 2012~Sep, 2013


論文著作區

C. Lin, M.-T. Lo, and C. Guilleminault, “Exploring the Abnormal Modulation of the Autonomic Systems during Nasal Flow Limitation in Upper Airway Resistance Syndrome by Hilbert–Huang Transform” Frontiers in Medicine, 4:161, 2017

C. Lin, Y. C. Chang, Y.C. Cheng, P. J. Lai, C. H. Yeh, W.H. Hsieh, K. Hu, J. T. Wu, H. H.Lee, M. T. Lo, and Y. L. Ho.. Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System. Scientific reports 6: 31950, 2016.

l  Lin YH, Wu VC, Lo MT, Wu XM, Hung CS, Wu KD, Lin C#, Ho YL, Stowasser M, and Peng CK. “Reversible heart rhythm complexity impairment in patients with primary aldosteronism.” Scientific reports 5: 11249, 2015.  (#equal correspondence)

C. Lin and M.-T Lo “Recent Progresses in Sleep Monitoring”, Formosan Journal of Medicine, 2014 Mar; 18(2): 172-180 

l  Y. H. Lin, C. Lin, Y. H. Ho, V. C. Wu, M. T. Lo, K. Y. Hung, L. Y. D. Liu, L. Y. Lin, J. W. Huang, C. K. Peng “Heart rhythm complexity impairment in patients undergoing peritoneal dialysis” Scientific Reports 6: 28202 2016

l  Y. Lin, C. Lin, I.-W Sun, C.-C. Hsu, C.-K Fang, M.-T. Lo, H.-C. Huang, and S.-I. Liu “Resting Respiratory Sinus Arrhythmia is Related to Longer Hospitalization in Mood-disordered Repetitive Suicide Attempters” World J of Biol Psychia  2015

l  P.-H. Tsai, C. Lin, J. Tsao, P.-F. Lin, P.-C. Wang, N.E. Huang, M.-T. Lo, Empirical mode decomposition based detrended sample entropy in electroencephalography for Alzheimer's disease. J Neurosci Methods, 2012 Sep 30; 210(2):230-7. 

l  Y.-L. Ho, C. Lin, Y.-H. Lin and M.-T. Lo, The prognostic value of non-linear analysis of heart rate variability in patients with congestive heart failure- A pilot study of multiscale entropy, PLoS One, 2011 Apr, 6(4), e18699. 

l  H.-K. Yuan, C. Lin, P.-H. Tsai, F.-C. Chang, K.-P. Lin, H.-H. Hu, M.-C. Su and M.-T. Lo, Acute increase of complexity in the neurocardiovascular dynamics following carotid stenting, Acta Neurol Scand, 2011 Mar, 123(3):187-9 

l  Y.-H. Lin*, C. Lin*, M.-T. Lo, H.-J. Lin, Y.-W. Wu, R.-B. Hsu, C.-L. Chao, H.-C. Hsu, P.-C. Wang, V.-C. Wu, S.-S. Wang, C.-M. Lee, K.-L. Chien, Y.-L. Ho, M.-F. Chen and C. K. Peng “The relation between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death”, Clin Chem Lab Med, 2010 Dec, 48(12):1821-7. 

l   J.-R. Yeh, L.-C. Hsu, C. Lin, F.-L. Chang and M.-T. Lo*, “Nonlinear Analysis of Sensory Organization Test for Subjects with Unilateral Vestibular Dysfunction”, PloS One, 2014 Mar; 9(3): e91230 

l  M.-T Lo, Y.-C. Chang, C. Lin, Vincent H.-W. Young, Y.-H. Lin, Y.-L. Ho, C.-K. Peng, K. Hu “Outlier-resilient complexity analysis of heartbeat dynamics” Scientific Reports  2015

l  M. Cao, C. Guilleminault, C. Lin, Central Sleep Apnea: Effects on Stroke Volume in Heart Failure, Am J Respir Crit Care Med, 2013 Feb, 187(4):340-1. (Letter to Editor)

l  Y.-J. Lin, M.-T. Lo, C. Lin, S.-L. Chang, L.-W. Lo, Y.-H. Hu, W.-H. Hsieh, H.-Y Chang, W.-Y Lin, F.-P. Chung, J. Liao, Y.-Y Chen, D. Hanafy, N.E. Huang, S.-A. Chen, Prevalence, Characteristics, Mapping, and Catheter Ablation of Potential Rotors in Non-Paroxysmal Atrial Fibrillation Circ Arrhythm Electrophysiol, 2013  Oct; 6(5):851-8 

l  Y.-J. Lin, M.-T. Lo, C. Lin, S.-L. Chang, L.-W. Lo, Y.-H. Hu, T.-F. Chao, C.-H. Li, Y.-C Chang, W.-H. Hsieh, F.-P. Chung, H.-M. Tsao, H.-Y Chang, N.E. Huang, S.-A. Chen, Nonlinear analysis of fibrillatory electrogram similarity to optimize the detection of complex fractionated electrograms during persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2013 Mar; 24(3): 280-9. 

l  Y.-H. Lin, H.-C. Huang, Y.-C. Chang, C. Lin, M.-T. Lo, L.-Y. D. Liu, P.-R. Tsai, Y.-S. Chen, W.-J. Ko, Y.-L. Ho, M.-F. Chen, C.-K. Peng and T. G. Buchman, “Multi-scale Symbolic Entropy Analysis Provides Prognostic Prediction in Patients Receiving Extracorporeal Life Support”, Critical Care, 2014 Oct 24; 18(5): 548 

l  Y.-J. Lin, K. Suenari, M.-T Lo, C. Lin, W.-H Hsieh, S.-L Chang, L.-W Lo, Y.-F Hu, C.-C Cheng, W.-S. Lin, Y. Kihara, T.-F. Chao, B. Hartono, T.-J Wu, N. E. Huang, S.-A. Chen, A Novel Assessment of the Temporal Variation in the Fractionated Electrograms Using a Histogram Analysis of the Local Fractionation Interval in Persistent Atrial Fibrillation Patients, Circ Arrhythm Electrophysio, 2012 Oct, 5(5):949-56. 

l  P.-F. Lin, J. Tsao, M.-T. Lo, C. Lin, Y.-C. Chang “Symbolic Entropy of the Amplitude rather than the Instantaneous Frequency of EEG Varies in Dementia”, Entropy, 2015 Jan; 17(2): 560-579  

l  L.-C. Wu, H.-H. Chen, J.-T. Horng, C. Lin, N.E. Huang, Y.-C. Cheng, and K.-F. Cheng, A Novel Preprocessing Method Using Hilbert Huang Transform for MALDI-TOF and SELDI-TOF Mass Spectrometry Data, PLoS One, 2010 Aug,5(8):e12493. 

l  L.-Y. Lin, M.-T. Lo, P. C.-I. Ko, C. Lin, W.-C. Chiang, Y.-B. Liu, M. H.-M. Ma, J.-L. Lin and W.-J. Chen, Detrended Fluctuation Analysis Predicts Successful Defibrillation for Out-of-Hospital Ventricular Fibrillation Cardiac Arrest, Resuscitation, 2010 Jan, 81(3): 297-301. 

l  M.-T. Lo, P.-H. Tsai, P.-F. Lin, C. Lin and Y.-L. Hsin, The Nonlinear and Nonstationary Prosperities in EEG Signals: Probing the Complex Fluctuations by Hilbert-Huang Transform, Advances in Adaptive Data Analysis, 2009 Jul, 1(3):461-482.

l  P.-F. Lin, M.-T. Lo, J. Tsao, Y.-C. Chang, C. Lin and Y.-L. Ho, “Correlations between the Signal Complexity of Cerebral and Cardiac Electrical Activity: A Multiscale Entropy Analysis”, PloS One, 2014 Feb; 9(2): e87798 

l  M.-T. Lo, L.-Y. Lin, W.-H. Hsieh, P.-C. Ko, Y.-B. Liu, C. Lin, Y.-C. Chang, C.-Y. Wang, V.-H. Young, W.-C. Chiang, J.-L. Lin, W.-J. Chen, M.-H Ma. “A New Method to Estimate the Amplitude Spectrum Analysis of Ventricular Fibrillation during Cardiopulmonary”, Resuscitation, 2013 Nov; 84(11): 1505–1511 

l   T.-C. Tuan, M.-T. Lo, Y.-J. Lin, W.-H. Hsieh, C. Lin, N. E. Huang, L.-W. Lo, T.-F. Chao, J. Liao, Y.-C. Hsieh, T.-J. Wu, S.-A. Chen, “The Use of Signal Analyses of Ventricular Tachycardia Electrograms to Predict the Response of Anti-tachycardia Pacing in Patients with Implantable Cardioverter-defibrillators”, Journal of Cardiovascular Electrophysiology, 2014 Apr; 25(4): 411-417 

l  Y.-C Liu, C.-S Hung, Y.-W Wu, Y.-C. Lee, Y.-H. Lin, C. Lin, M.-T. Lo, C.-C Chan, H.-P Ma, Y.-L. Ho, C.-H. Chen, Influence of non-alcoholic fatty liver disease on autonomic changes evaluated by the time domain, frequency domain, and symbolic dynamics of heart rate variability. PLoS One, 2013 Apr 23; 8(4): e61803 

l  L.-Y. Lin, M.-T. Lo, P. C.-I. Ko, W.-C. Chiang, C. Lin, K.-H Hsiung, J.-L. Lin , W.-J. Chen and M. H.-M. Ma, A new way to analyze resuscitation quality by reviewing automatic external defibrillator data, Resuscitation, 2012 Feb, 83(2):171-6. 

l  Y.-C. Chang, L.-K. Huon, V.-T. Pham, Y.-J. Chen, S.-F. Jiang, T. T.-F. Shih, T.-T. Tran, Y.-H. Wang, C. Lin, J. Tsao, M.-T. Lo and P-C Wang, "Synchronized imaging and acoustic analysis of the upper airway in patients with sleep-disordered breathing", Physiological Measurement, 2014 Dec; 35(12): 2501-12 


Conference

A.    Invited Speaker

·     “Probing the time-frequency representation of nonlinear and nonstationary signals by Hilbert-Huang transform”, The 2014 Annual meeting of Society of Exploration Geophysicists, Denver, U.S. (2014)

·     “The Use of Signal Analyses of Ventricular Tachycardia Electrograms to Predict the Response of Anti-tachycardia Pacing in Patients with Implantable Cardioverter-Defibrillators” 2015 THRS 1st International Forum of Ventricular Arrhythmia, Taipei, Taiwan (2015)

B.    Oral Presentation

l   “Alterations of circadian rest-activity rhythms in pediatric patients with type-1 narcolepsy during treatment.“ 2016 International Pediatric Sleep Association Congress, Taipei, Taiwan (2016)

l   “Changes of Electroencephalogram with flow limitation during NREM stage II sleep in patients with upper airway resistance syndrome evaluated by a novel respiratory cycle-based analysis.” 2014 Annual Meeting of American Academy of Sleep Medicine, Minneapolis, USA (2014)

l   “Different activation of autonomic nervous system with flow limitation”, The 2013 World Congress on Sleep Medicine, Valencia, Spain (2013)

l   “A new way to analyze resuscitation quality by reviewing automatic external defibrillation data”, The 3rd International Conference on Hilbert-Huang Transform, Qingdao, China (2011)

研究計畫區

· 2014-2017  Realization of a wearable device for biomarker detection and cloud computation based feedback (Subproject 3 :  Exploiting biomarkers of physiological signals recorded from wearable devices by using adaptive data analysis) 

· 2014-2016  Industrial Technology Development Program- Smart Health Care Wearable Devices with Soft Screen (Subproject: Developing wearable vital sign monitoring and extracting the precursors of cardiovascular diseases)

· 2015 Infinitus Inc. (Hong Kong) – Qi index as an approximate of neural-regulated immunity derived from wearable ECG devices. 

· 2016 Flow Inc.- Using the dynamical biomarkers of multiple physiological signals as a surrogate for minor allergic reaction. 

· 2017 Industry-Academy cooperation project of Hsinchu Science Park Bureau-“An integrated platform for early screening of sleep breathing disorders.” 

· 2017 Joint Project of National Central University and Landseed Hospital-Exploring the associations among in-patient longitudinal changes of vital signs, laboratory data of acute exacerbations of chronic obstructive pulmonary disease and their prognosis by machine learning.” 

專利區
  • Method and system for extracting ventricular fibrillation signals in electrocardiogram  using  spline interpolation with uniform phase ensembles US 9451898 B2 Sep, 2016
  • System and method for quantitative analysis of respiratory sinus arrhythmia US 9380948 B1 Jul, 2016
  • Method and system for extracting ventricular fibrillation signals in electrocardiogram, US 9259167 B2 Feb, 2016