專任教師-系統生物與生物資訊組   首頁 師資介紹 專任教師-系統生物與生物資訊組
許藝瓊 助理教授 Yi-Chiung Hsu
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專線電話:03-4227151轉36102
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E-mail :syic@ncu.edu.tw
學經歷

學歷:

國立陽明大學藥理學研究所 博士

台北醫學大學藥學系 學士


經歷:

中研院統計所     博士後研究員    

中國文化大學/園藝暨生物技術學系 兼任助理教授

台灣大學/內科    博士後研究員

台灣師範大學/生命科學系 兼任助理教授

論文著作區

Journal Papers

1. Yi-Chiung Hsu, Hsin-Chen Lee, Yueh-Hsin Ping, Tsung-Yun Liu,Wing-Yiu Lui, Chin-Wen Chi, Mitochondria are an essential mediator of NO/cGMP blocking of glucose depletion induced cytotoxicity in human HepG2 cells. Molecular Cancer Research, 2007; 5: 923–32.

2. Yuh-Fang Chang #, Yi-Chiung Hsu #, Hui-Ju Lee, Hui-Fang Hung, Wing-Yiu Lui, Chin-Wen Chi, Jane-Jen Wang, Quercetin induces oxidative stress and potentiates the apoptotic action on the 2-methoxyestradiol in  human hepatoma cell lines. Nutrition and Cancer, 2009; 61:735-45.  # means equal contribution.

3. Yi-Chiung Hsu, Shinsheng Yuan, Hsuan-Yu Chen, Sung-Lian Yu, Chia-Hsin Liu, Pin-Yen Hsu, Guani

Wu, Chia-Hung Lin, Gee-Chen Chang, Ker-Chau Li, and Pan-Chyr Yang,

A four-gene signature from NCI-60 cell line for survival prediction in non–small-cell lung cancer.

  Clinical Cancer Research, 2009; 15: 7309-15.

4. Shih-Ping Cheng, Pen-Hui Yin, Yi-Chiung Hsu, Yuan-Ching Chang, Shih-Yuan Huang, Jie-Jen Lee and Chin-Wen Chi, Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways. Oncology Reports, 2011; 26:1265-71.

5. Shinsheng Yuan, Sung-Liang Yu, Hsuan-Yu Chen, Yi-Chiung Hsu, et. al., Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. Journal of clinical oncology, 2011; 29:3435-42.

6. Jane-Jen Wang, Hui-Fang Hung, Min-Li Huang, Hui-Ju Lee, Yaw-Terng Chern, Yuh-Fang Chang, Chin-Wen Chi, Yi-Chiung Hsu. Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells. Oncology Reports, 2012; 27: 529-34.

7. Shih-Ping Cheng, Chien-Liang Liu, Yi-Chiung Hsu, Yuan-Ching Chang, Shih-Yuan Huang, Jie-Jen Lee. Regulation of leptin receptor expression in human papillary thyroid cancer cells. Biomedicine Pharmacotherapy 2012; 66: 469-73.

8. Shih-Ping Cheng, Chien-Liang Liu, Yi-Chiung Hsu, Yuan-Ching Chang, Shih-Yuan Huang, Jie-Jen Lee. Expression and biological significance of adiponectin receptors in papillary thyroid carcinoma. Cell Biochemistry and Biophysics. 2013; 65: 203-10.

9. Chien-Liang Liu, Jie-Jen Lee, Tsang-Pai Liu, Yuan-Ching Chang Yi-Chiung Hsu, and Shih-Ping Cheng.

  Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. Journal of Surgical Oncology. 2013: 107: 493-7..

10. Hsien Liang, Szu-ying Chiu, I-Ling Hsu, Yi-Ying Wu, Yao-Tsung Tsai, Jhen-Yu Ke, Szu-Hua Pan, Yi-Chiung Hsu, Ker-Chau Li, Pan-Chyr Yang, Yuh-Ling Chen, and Tse-Ming Hong. α-catulin drives metastasis by activating ILK and driving an avß3 integrin signaling axis. Cancer Research 2013; 73: 428-38.

11. Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Lian Yu, Chia-Hung Lin, Guani

   Wu, Pan-Chyr Yang and Ker-Chau Li. Genome-wide analysis of three-way interplay between gene expression, cancer cell invasion and anti-cancer compound sensitivity. BMC Medicine 2013; 11: 106.

12. Pei-Fang Hung, Tse-Ming Hong, Yi-Chiung Hsu, Hsuan-Yu Chen, Yih-Leong Chang, Chen-Tu Wu, Gee-Chen Chang, Yuh-Shan Jou, Szu-Hua Pan and Pan-Chyr Yang. The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma. PLOS ONE. 2013; 8: e61664

13. Wen-Lung Wang, Hsiao-Chun Huang, Shih-Han Kao, Yi-Chiung Hsu, Yi-Ting Wang, Ker-Chau Li, Yu-Ju Chen, Sung-Liang Yu, Shu-Ping Wang, Tzu-Hung Hsiao, and Pan-Chyr Yang. Slug is temporally regulated by cyclin E in cell cycle and controls genome stability, Oncogene. 2015, 34: 1116-25.

14. Yuan-Ching Chang, Yi-Chiung Hsu, Chien-Liang Liu, Shih-Yuan Huang, Meng-Chun Hu1, Shih-Ping Cheng. Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PLOS ONE, 2014, 9: e89563.

15. Shih-Ping Cheng, Yi-Chiung Hsu, Chien-Liang Liu, Tsang-Pai Liu, Ming-Nan Chien, Tao-Yeuan Wang, and Jie-Jen Lee. Significance of allelic percentage of BRAF c.1799T>A (V600E) mutation in papillary thyroid carcinoma. Annals of Surgical Oncology. 2014, Suppl 4:S619-26

16. Shih-Ping Cheng, Chien-Liang Liu, Tsang-Pai Liu, Yi-Chiung Hsu and Jie-Jen Lee. Association between parathyroid hormone levels and inflammatory markers among US adults. Mediators Inflammation. 2014, 2014:709024

17. Wen-Ching Ko, Chien-Liang Liu, Jie-Jen Lee, Tsang-Pai Liu, Po-Sheng Yang, Yi-Chiung Hsu, and Shih-Ping Cheng. Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate Concentrations in U.S. Adults: The National Health and Nutrition Examination Survey 2005–2006. PLOS ONE, 2014, 9: e115245.

18. Shih-Ping Cheng, Chien-Liang Liu, Ming-Jen Chen, Ming-Nan Chien, Ching-Hsiang Leung, Chi-Hsin

   Lin, Yi-Chiung Hsu, and Jie-Jen Lee. CD74 expression and its therapeutic potential in thyroid carcinoma.

   2015, 22 :179-90.

19. Hsuan-Yu Chen, Sung-Liang Yu, Bing-Ching Ho, Kang-Yi Su, Yi-Chiung Hsu, Chi-Sheng Chang,

   Yu-Cheng Li, Shi-Yi Yang, Pin-Yen Hsu, Hao Ho, Ya-Hsuan Chang, Chih-Yi Chen, Hwai-I Yang,

   Chung-Ping Hsu, Tsung-Ying Yang, Kun-Chieh Chen, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Jiun-Yi Hsia,

   Cheng-Yen Chuang, Shinsheng Yuan, Mei-Hsuan Lee, Chia-Hsin Liu, Guan-I Wu, Chao A. Hsiung,

   Yuh-Min Chen, Chih-Liang Wang, Ming-Shyan Huang, Chong-Jen Yu, Kuan-Yu Chen, Ying-Huang

   Tsai, Wu-Chou Su, Huei-Wen Chen, Jeremy J.W. Chen, Chien-Jen Chen, Gee-Chen Chang, Pan-Chyr

   Yang and Ker-Chau Li. R331W missense mutation of oncogene YAP1 is a germline risk allele for lung

   adenocarcinoma with medical actionability. Journal of clinical oncology, 2015, 33: 2303-10.

20. Po-Sheng Yang, Jane-Jen Wang, Yea-Hwey Wang, Woan-Ching Jan, Shih-Ping Cheng, Yi-Chiung Hsu.

   1,6-Bis [4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD) potentiates in-vitro and in-vivo

   antitumor effects of irinotecan (CPT-11) on human colon cancer cells. Oncology Letters, 2015, accepted.

 

 

 

Conference Papers

1. Chin-Yin Lin,Yi-Chiung Hsu, Shih-Fen Liau, Yuan-Hsun Hsu, Characterization of the antioxidant AMBL-019C-TS produced by the soil-borne isolate of Streptomyces macrosporeus. 2001 the Chinese society of microbiology,Taipei,Taiwan.

2. Yi-Chiung Hsu, Chin-Wen Chi, Modulation of mitochondrial biogenesis by nitric oxide during glucose deprivation in human hepatoma cells. 2006 The 97th American Association for Cancer Research annual meeting,WashingtonDC,USA. (AACR Meeting Abstracts, Apr 2006; 2006: 313.)

3. Yi-Chiung Hsu, Hsin-Chen Lee, Yueh-Hsin Ping, Tsung-Yun Liu,Wing-Yiu Lui, Chin-Wen Chi, Mitochondria are an essential mediator of nitric oxide blocking the glucose depletion-induced cytotoxicity in human HepG2 cells. 2007 The 22th Joint Annual Conference of Biomedical Sciences,Taipei,Taiwan. (2007/03/18Oo47)

4. Yi-Chiung Hsu, Shin-sheng Yuan, Sung-Liang Yu, Huei-Wen Chen, Pan-Chyr Yang, Ker-Chau Li,

Genome-wide study of embryonic stem cell markers, OCT4 and NANOG, in the NCI human tumor cell line

gene expression database. 2008 The 6th International Society for Stem Cell Research annual meeting,PHL,USA.

5. Yi-Chiung Hsu, Shinsheng Yuan, Hsuan-Yu Chen , Pan-Chyr Yang, Ker-Chau Li,

  An invasion-associated gene signature predicts clinical outcome in non–small-cell lung cancer. 2008   

  HUGO HCCS Workshop,Singapore. (Young Scientist Travel Award)

6. Yi-Chiung Hsu, Shinsheng Yuan, Hsuan-Yu Chen , Chia-Hsin Liu, Pan-Chyr Yang, Ker-Chau Li,

Stem cell-associated gene signature in non-small-cell lung cancer. 2009 The 7th International Society for Stem Cell Research annual meeting,Barcelona,Spain.

7. Yi-Chiung Hsu, Shinsheng Yuan, Hsuan-Yu Chen , Sung-Liang Yu, Cin-Di Wang, Pan-Chyr Yang, Ker-Chau Li, Invasion-associated genetic markers predict clinical outcome of non–small-cell lung cancer patients. 2009, 13th World Conference on Lung Cancer,San Francisco,USA.

8. Yi-Chiung Hsu and Ker-Chau Li, Conjugate sensitivity to anti-mitotic chemotherapy versus targeted

therapy is revealed and predicted by tumor-invasion gene-expression profiling 2011 Conference on risk

assessment and evaluation of predictions. Washington DC, USA.

9. Yi-Chiung Hsu, Hsuan-Yu Chen, Pan-Chyr Yang and Ker-Chau Li. Phenotype profiling of cancer cell    

  invasion identified unique signature that can predict chemotherapeutic response in lung cancer. 2012, 5th

  Asia Pacific Lung Cancer Conference. Fukuoka, Japan. (Young Scientist Travel Award)

10. Yi-Chiung Hsu, Hsuan-Yu Chen, Chia-Hung Lin and Ker-Chau Li. Integrative analysis of invasion

  signature and drug responsiveness in NCI60 cancer cell lines. 2013, The 9th ICSA International

  Conference:

  Challenges of Statistical Methods for Interdisciplinary Research and Big Data. Hong Kong.

11.Yi-Chiung Hsu, Hsuan-Yu Chen, and Ker-Chau Li. Copy number variation analysis in cancer cell lines

  during cell cycle progression. 2014, 73rd Annual Meeting of the Japanese Cancer Association. Yokohama,

  Japan. (Young Scientist Travel Award)

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