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李弘謙 生物物理講座教授 Hoong-Chien Paul Lee
從聘系所: 生醫科學與工程學系 系統生物與生物資訊研究所
專線電話:03-4227151轉36109
傳真電話:
學經歷

Biosketch

 

H. C. (Paul) Lee

University Chair Professor of Biophysics

Adjuct Professor, Graduate Institute of Systems Biology and Bioinformatics

National Central University

University Chair Professor of Physics

Chung Yuan Christian University

 

tel: (+886-3) 422-7151 ext. 36109/27733

fax: (+886-3) 427-3822

e-mail: hclee12345 at gmail dot com

URL: http://sansan.phy.ncu.edu.tw/~hclee/ or Google: HC Paul Lee

 

  Dr. H.C. Lee is University Chair Professor of Biophysics at the National Central University and University Chair Professor of Physics at Chung Yuan Christian University, and was a Ministry of Education National Chair Professor (2006-2009). He was educated at the Taipei Subordinate Middle School of the Normal University (1953-1959), National Taiwan University (BSc, 1963) and McGill University (MSc. 1967; PhD, 1969). Dr. Lee was employed at the Canadian Chalk River Research Laboratories as a theoretical physicist from 1968 to 1993, progressing from postdoctoral fellow in 1968 to senior research officer in 1984. In 1992-1993 he was founding director of the Center for Mathematical Sciences. During this period his field of research was, in succession, nuclear physics, particles and fields, and mathematical physics. He also visited and worked at University of Toronto, McGill, Brookhaven National Labs., Niels Bohr Institute, National Taiwan University, Cambridge University, and Beijing Institute of Theoretical Physics.

 

  In 1993 Dr. Lee returned to Taiwan, first chairing the physics department of the National Chung Hsing University from 1993 to 1995, then moving to the National Central University in 1995. In 1997 he turned to theoretical and quantitative biology, focusing on molecular evolution through the study of physical and statistical properties of genomic sequences. Since 2006 his work has focused on the biomedical application of computational genomics, especially on topics related to the understanding of complex disease and the discovery of repurposed drugs for their treatments. At NCU Dr. Lee was professor at the Department of Physics (1995-2006), and founding head of the Graduate Institute of Systems Biology and Bioinformatics (2006-2012). Since February 2012 Dr. Lee has been a faculty member of the Physics Department, CYCU. 


論文著作區

Biomedicine related (2011 and after)


  1. Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo. MH Lee, et al., and NS Chang*. Oncotarget 6(6): 3737-3751 (2015) (PDF)

  2.  Method designed to respect molecular heterogeneity can profoundly correct present data interpretations for genome-wide expression analysis. CH Chen, CL Hsu, SH Huang, SY Chen, YL Hung, HR Chen, YC Wu, LJ Su, and HC Lee. PLoS ONE 10(3):e0121154 (2015) (PDF)

  3. miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2. SM Liu, Jean Lu, HH Lee, FH Chung and Nianhan Ma. Oncotarget 5(19): 9444-9457 (2014) (PDF)

  4. Functional Module Connectivity Map (FMCM): A framework for searching repurposed drug compounds for systems treatment of cancer and an application to colorectal adenocarcinoma. FH Chung, YR Chiang, AL Tseng, YC Sung, Jean Lu, MC Huang, NH Ma, HC Lee. PLoS ONE 9(1): e86299 (2014) (PDF)

  5. Cystatin C in cerebrospinal fluid is upregulated in elderly patients with chronic osteoarthritis pain and modulated through matrix metalloproteinase 9-specific pathway. Guo SL, Han CT, Jung JL, Chen WJ, Mei JJ, Lee HC, Cheng YC. Clin J Pain. 2013 30(4):331-9. (PDF)

  6. A Trend-of-Disease-Progression procedure works well for identifying cancer genes from multi-state cohort gene expression data for human colorectal cancer. FH Chung, HHC Lee, HC Lee. PLoS ONE 8(6): e65683 (2013) (PDF)

  7. Microarray analysis and establishment of drug screening platform using 5-fluorouracil resistance HCT116 colon cancer cells. AL Tseng, FH Chung, HC Lee, LC Wu, CH Chen, LJ Su. Genomic Medicine, Biomarkers, and Health Sciences 4(1-2): 21-27 (2012) (PDF)

  8. A Fast Universal Immobilization of Immunoglobulin G at 4uC for the Development of Array-based Immunoassays. SL Guo, PC Chen, MS Chen, YC Cheng, JM Lin, HC Lee, CS Chen. PLoS ONE 7(12): e51370 (2012) (PDF)

  9. An all-statistics, high-speed algorithm for the analysis of copy number variation in genomes. CH Chen, HHC Lee, QD Ling, HR Chen, YA Ko, TS Tsou, SC Wang, LC Wu, HC Lee. Nucleic Acids Research 39, e89 (2011) (PDF)

 

All publications

Genome and quantitative molecular evolution

- Dusty plasma

- Quantum algebra and knot theory

- Quantum field theory

- Medium energy

- Nuclear structure



研究計畫區
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