專任教師-系統生物與生物資訊組   首頁 師資介紹 專任教師-系統生物與生物資訊組
劉淑貞 助理教授 Shu-Chen Liu
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學經歷

Education:


2009   Ph.D.     國防醫學院/中央研究院/國家衛生研究院合辦,生命科學研究科所

2000   M.S.   國立陽明大學醫學工程暨技術學院,放射醫學科學研究所


Experience
:


2016-present     Assistant professor

                            Department of Biomedical Sciences and Engineering,

                            National Central University


2015-2016/01   Assistant research scholar

                            Department of Biomedical Sciences and Engineering,

                            National Central University


2009-2015       Postdoctoral research fellow

                            Molecular Medicine Research Center, Chang Gung University


2001-2009       Ph.D. program

                            Division of Molecular and Genomic Medicine,

                            National Health Research Institutes


Conference abstracts


Shu-Chen Liu, Tien Hsu, Chiou-Hwa Yuh, Ngan-Ming Tsang. Cytoplasmic LIF Reprograms Cancer Invasive Modes to Facilitate Metastasis and Enhance Multidrug Resistance. The 22nd Taiwan Joint Cancer Conference (2017, May)


Shu-Chen Liu, Ngan-Ming Tsang, Tien Hsu, Yu-Sun Chang. Leukemia inhibitory factor drives invadopodia formation and genome instability. 2016 17th International Symposium on EBV and associated diseases (Zurich, Switzerland). Zurich, Switzerland.


Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance (Oral presentation). 2014 Academic Conference of TASTRO & The 4th Annual Meeting of TAROS.

 

Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Poster presentation). 2014 16th International Symposium on EBV and Associated Diseases (Brisbane, Australia).

 

Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Oral & poster presentation). 2014 The 19th Taiwan Joint Cancer Conference.

 

Shu-Chen Liu, Ngan-Ming Tsan, Wen-Che Chiang, Kai-Ping Chang, Chuen Hsueh, Ying Liang, Yu-Sun Chang. LIF regulates p70S6K to promote progressiveness and radioresistance of NPC (Poster presentation). EBV 50th Anniversary, 23rd - 25th March 2014, Keble College Oxford.

 

Shu-Chen Liu. Functional monitoring of thrombin-induced responses in cancer cells (Oral presentation, invited speaker). xCELLigence Symposium” and the “APAC xCELLigence User Meeting 2010”. Beijing, China.

 

Shu-Chen Liu, Yee-Min Jen, Shih Sheng Jiang, Junn-Liang Chang, Chao A. Hsiung, Chih-Hung Wang, Jyh-Lyh Juang. Ga12-dependent pathway promotes tumorigenesis and metastasis of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization (Oral presentation). 2009 Research Day, National Health Research Institutes, Taiwan.

 

Honors

-2017 The 22th Taiwan Joint Cancer Conference Award

-2014 Awards of The Cancer Prevention & Treatment Foundation

-2014 The 19th Taiwan Joint Cancer Conference Poster Award

-2011 NHRI Outstanding Paper Award

-Awarded for excellent thesis in 2009 NHRI Research Day

 

Professional Memeberships:


2004-Present         Taiwan Society for Therapeutic Radiology and Oncology (台灣放射腫瘤學會)



論文著作區

Publications


  1. Wu TS1, Wang LC1, Liu SC1, Hsu TY, Lin CY, Feng GJ, Chen JM, Liu HP, Chung IC, Yen TC, Chang YS, Liao SK, Chang C, Chow KP. EBV Oncogene N-LMP1 Induces CD4 T Cell–Mediated Angiogenic Blockade in the Murine Tumor Model. J Immunol. 2015 Apr 6. (1co-first author). (highlight article, IF: 5.362, ranking: 24/144)

  2. Liu SC and Chang YS. Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis. Molecular & Cellular Oncology. 2014 Jul 15 1(1): e29900.

  3. Hsu CW, Yu JS, Peng PH, Liu SC, Chang YS, Chang KP, Wu CC. Secretomic profiling of primary cells reveals that THBS2 is a salivar biomarker of oral cavity squamous cell carcinoma. J Proteome Res. 2014 Nov 7;13(11):4796-807. (IF: 5.001, ranking: 10/75)

  4. Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest. 2013 Dec 2;123(12):5269-83. (highlight article, IF: 13.765, ranking: 3/124)

  5. Liu HP, Chen CC, Wu CC, Huang YC, Liu SC, Liang Y, Chang KP, Chang YS.  Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 2012 May;8(5):e1002690. (IF: 8.057, ranking: 10/119)

  6. Peng PH, Wu CC, Liu SC, Chang KP, Chen CD, Chang YT, Hsu CW, Chang YS, Yu JS. Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J Proteomics. 2011 May 1;74(5):744-57. (IF: 3.973, ranking: 14/78)

  7. Chen HC, Ma HI, Sytwu HK, Wang HW, Chen CC, Liu SC, Chen CH, Chen HK, Wang CH. Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. J Neurosci Res. 2010 Nov 15;88(15):3308-18. (IF: 2.729, ranking: 141/251)

  8. Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res. 2009 Aug 1;69(15):6122-30. (IF: 9.284, ranking: 10/203)

  9. Jiang SS, Chang IS, Huang LW, Chen PC, Wen CC, Liu SC, Chien LC, Lin CY, Hsiung CA, Juang JL. Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus. J Virol. 2006 Sep; 80(18):8989-99. (IF: 4.648, ranking: 6/34)

  10. Wen CC, Wu YJ, Huang YH, Chen WC, Liu SC, Jiang SS, Juang JL, Lin CY, Fang WT, Hsiung CA, Chang IS. A Bayes regression approach to array-CGH data. Stat Appl Genet Mol Biol. 2006;5: Article3. (IF: 1.055, ranking: 48/119)



研究計畫區

1.     EBV病毒調控脂肪細胞分化並重建腫瘤微環境(科技部2015/8/1~2018/7/31)

2.     白血病抑制因子重建侵犯模式增強癌侵犯性(榮台聯大計畫 2017/01/01~2017/12/31)

3.     白血病抑制因子亞型在癌化過程所扮演的角色(科技部2016/8/1~2017/7/31,共同主持人)

4.     鼻咽癌病人治療中皮下脂肪的增加會減低鼻咽局部復發率(科技部,共同主持人)

5.     Next-Generation Sequencing for identification of genetic determinants in radioresistant nasopharyngeal carcinoma(長庚醫院,共同主持人2013/01/01~2015/12/31).

6.     The area of subcutaneous fat component could reflect the survival outcome in phargo-laryngeal cancer patients(長庚醫院,共同主持人, 2014/10/01~2015/09/30)



專利區

Patent


l  評估癌症於治療後情況的方法及其相關應用 (中國)( CN 104623663 A; 專利期限 2017 2035)

l   鼻咽癌治療的醫藥  (台灣,發明第I486172,專利期間:2015/06~2033/11)

l   Potentiation of nasopharyngeal cancer radiotherapy by inhibitors of leukemia inhibitory factor
(發明專利US9,194,872 B2 (2015/11/24~2034))

l   Diagnosis of nasopharyngeal carcinoma and suppression of nasopharyngeal carcinoma invasion.
(US 20100003257 A1)