專任教師-跨領域轉譯醫學組   首頁 師資介紹 專任教師-跨領域轉譯醫學組
林澂 助理教授 Chen Lin
從聘系所:
專線電話:03-4227151轉27756
傳真電話:
E-mail :clin@ncu.edu.tw
學經歷

Education

National Central University, Taiwan

Ph.D. in Institute of Systems Biology and Bioinformatics

September, 2008 ~ July, 2012

National Yang Ming University, Taiwan

M.S.of Institute of Physiology

September, 2002 ~ June, 2004


Dissertation


Ph.D. Degree

Title: “Application of Hilbert-Huang Transform in Exploring the Nonlinear Characteristics of Biomedical Signals”

Advisor: Prof. Norden Er Huang


M.S. Degree

Title: ”Short-term and long-term outcome assessment in surgical critically-ill patients-linear and nonlinear analyses of heart rate dynamics”

Advisor: Prof. Yu Ru Kou

 


Academic and professional experiences

Assistant Professor

Department of Biomedical Sciences and Engineering, National Central University

Aug, 2015~

Assistant Research Fellow

Center for Adaptive Data Analysis, National Central University

Feb, 2014~Jul, 2015

Taiwanese Team of Qualcomm Tricorder XPRIZE Competition (Co-PI in Vital Sign Group)

Sep, 2013~April, 2017

Post-Doctoral Fellow

Department of Behavioral Science and Psychiatry, Stanford University

Sep, 2012~Sep, 2013


論文著作區

l  C. Lin, M.-T. Lo, and C. Guilleminault, “Exploring the Abnormal Modulation of the Autonomic Systems during Nasal Flow Limitation in Upper Airway Resistance Syndrome by Hilbert–Huang Transform” Frontiers in Medicine, 4:161, 2017

l  C. Lin, Y. C. Chang, Y.C. Cheng, P. J. Lai, C. H. Yeh, W.H. Hsieh, K. Hu, J. T. Wu, H. H.Lee, M. T. Lo, and Y. L. Ho.. Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System.Scientific reports 6: 31950, 2016.

l  Lin YH, Wu VC, Lo MT, Wu XM, Hung CS, Wu KD, Lin C#, Ho YL, Stowasser M, and Peng CK. “Reversible heart rhythm complexity impairment in patients with primary aldosteronism.” Scientific reports 5: 11249, 2015.  (#equal correspondence)

l  C. Lin and M.-T Lo “Recent Progresses in Sleep Monitoring”, Formosan Journal of Medicine, 2014 Mar; 18(2): 172-180 

l  Y. H. Lin, C. Lin, Y. H. Ho, V. C. Wu, M. T. Lo, K. Y. Hung, L. Y. D. Liu, L. Y. Lin, J. W. Huang, C. K. Peng “Heart rhythm complexity impairment in patients undergoing peritoneal dialysis” Scientific Reports 6: 28202 2016

l  Y. Lin, C. Lin, I.-W Sun, C.-C. Hsu, C.-K Fang, M.-T. Lo, H.-C. Huang, and S.-I. Liu “Resting Respiratory Sinus Arrhythmia is Related to Longer Hospitalization in Mood-disordered Repetitive Suicide Attempters” World J of Biol Psychia  2015

l  P.-H. Tsai, C. Lin, J. Tsao, P.-F. Lin, P.-C. Wang, N.E. Huang, M.-T. Lo, Empirical mode decomposition based detrended sample entropy in electroencephalography for Alzheimer's disease. J Neurosci Methods, 2012 Sep 30; 210(2):230-7. 

l  Y.-L. Ho, C. Lin, Y.-H. Lin and M.-T. Lo, The prognostic value of non-linear analysis of heart rate variability in patients with congestive heart failure- A pilot study of multiscale entropy, PLoS One, 2011 Apr, 6(4), e18699. 

l  H.-K. Yuan, C. Lin, P.-H. Tsai, F.-C. Chang, K.-P. Lin, H.-H. Hu, M.-C. Su and M.-T. Lo, Acute increase of complexity in the neurocardiovascular dynamics following carotid stenting, Acta Neurol Scand, 2011 Mar, 123(3):187-9 

l  Y.-H. Lin*, C. Lin*, M.-T. Lo, H.-J. Lin, Y.-W. Wu, R.-B. Hsu, C.-L. Chao, H.-C. Hsu, P.-C. Wang, V.-C. Wu, S.-S. Wang, C.-M. Lee, K.-L. Chien, Y.-L. Ho, M.-F. Chen and C. K. Peng “The relation between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death”, Clin Chem Lab Med, 2010 Dec, 48(12):1821-7. 

l   J.-R. Yeh, L.-C. Hsu, C. Lin, F.-L. Chang and M.-T. Lo*, “Nonlinear Analysis of Sensory Organization Test for Subjects with Unilateral Vestibular Dysfunction”, PloS One, 2014 Mar; 9(3): e91230 

l  M.-T Lo, Y.-C. Chang, C. Lin, Vincent H.-W. Young, Y.-H. Lin, Y.-L. Ho, C.-K. Peng, K. Hu “Outlier-resilient complexity analysis of heartbeat dynamics” Scientific Reports  2015

l  M. Cao, C. Guilleminault, C. Lin, Central Sleep Apnea: Effects on Stroke Volume in Heart Failure, Am J Respir Crit Care Med, 2013 Feb, 187(4):340-1. (Letter to Editor)

l  Y.-J. Lin, M.-T. Lo, C. Lin, S.-L. Chang, L.-W. Lo, Y.-H. Hu, W.-H. Hsieh, H.-Y Chang, W.-Y Lin, F.-P. Chung, J. Liao, Y.-Y Chen, D. Hanafy, N.E. Huang, S.-A. Chen, Prevalence, Characteristics, Mapping, and Catheter Ablation of Potential Rotors in Non-Paroxysmal Atrial Fibrillation Circ Arrhythm Electrophysiol, 2013  Oct; 6(5):851-8 

l  Y.-J. Lin, M.-T. Lo, C. Lin, S.-L. Chang, L.-W. Lo, Y.-H. Hu, T.-F. Chao, C.-H. Li, Y.-C Chang, W.-H. Hsieh, F.-P. Chung, H.-M. Tsao, H.-Y Chang, N.E. Huang, S.-A. Chen, Nonlinear analysis of fibrillatory electrogram similarity to optimize the detection of complex fractionated electrograms during persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2013 Mar; 24(3): 280-9. 

l  Y.-H. Lin, H.-C. Huang, Y.-C. Chang, C. Lin, M.-T. Lo, L.-Y. D. Liu, P.-R. Tsai, Y.-S. Chen, W.-J. Ko, Y.-L. Ho, M.-F. Chen, C.-K. Peng and T. G. Buchman, “Multi-scale Symbolic Entropy Analysis Provides Prognostic Prediction in Patients Receiving Extracorporeal Life Support”, Critical Care, 2014 Oct 24; 18(5): 548 

l  Y.-J. Lin, K. Suenari, M.-T Lo, C. Lin, W.-H Hsieh, S.-L Chang, L.-W Lo, Y.-F Hu, C.-C Cheng, W.-S. Lin, Y. Kihara, T.-F. Chao, B. Hartono, T.-J Wu, N. E. Huang, S.-A. Chen, A Novel Assessment of the Temporal Variation in the Fractionated Electrograms Using a Histogram Analysis of the Local Fractionation Interval in Persistent Atrial Fibrillation Patients, Circ Arrhythm Electrophysio, 2012 Oct, 5(5):949-56. 

l  P.-F. Lin, J. Tsao, M.-T. Lo, C. Lin, Y.-C. Chang “Symbolic Entropy of the Amplitude rather than the Instantaneous Frequency of EEG Varies in Dementia”, Entropy, 2015 Jan; 17(2): 560-579  

l  L.-C. Wu, H.-H. Chen, J.-T. Horng, C. Lin, N.E. Huang, Y.-C. Cheng, and K.-F. Cheng, A Novel Preprocessing Method Using Hilbert Huang Transform for MALDI-TOF and SELDI-TOF Mass Spectrometry Data, PLoS One, 2010 Aug,5(8):e12493. 

l  L.-Y. Lin, M.-T. Lo, P. C.-I. Ko, C. Lin, W.-C. Chiang, Y.-B. Liu, M. H.-M. Ma, J.-L. Lin and W.-J. Chen, Detrended Fluctuation Analysis Predicts Successful Defibrillation for Out-of-Hospital Ventricular Fibrillation Cardiac Arrest, Resuscitation, 2010 Jan, 81(3): 297-301. 

l  M.-T. Lo, P.-H. Tsai, P.-F. Lin, C. Lin and Y.-L. Hsin, The Nonlinear and Nonstationary Prosperities in EEG Signals: Probing the Complex Fluctuations by Hilbert-Huang Transform, Advances in Adaptive Data Analysis, 2009 Jul, 1(3):461-482.

l  P.-F. Lin, M.-T. Lo, J. Tsao, Y.-C. Chang, C. Lin and Y.-L. Ho, “Correlations between the Signal Complexity of Cerebral and Cardiac Electrical Activity: A Multiscale Entropy Analysis”, PloS One, 2014 Feb; 9(2): e87798 

l  M.-T. Lo, L.-Y. Lin, W.-H. Hsieh, P.-C. Ko, Y.-B. Liu, C. Lin, Y.-C. Chang, C.-Y. Wang, V.-H. Young, W.-C. Chiang, J.-L. Lin, W.-J. Chen, M.-H Ma. “A New Method to Estimate the Amplitude Spectrum Analysis of Ventricular Fibrillation during Cardiopulmonary”, Resuscitation, 2013 Nov; 84(11): 1505–1511 

l   T.-C. Tuan, M.-T. Lo, Y.-J. Lin, W.-H. Hsieh, C. Lin, N. E. Huang, L.-W. Lo, T.-F. Chao, J. Liao, Y.-C. Hsieh, T.-J. Wu, S.-A. Chen, “The Use of Signal Analyses of Ventricular Tachycardia Electrograms to Predict the Response of Anti-tachycardia Pacing in Patients with Implantable Cardioverter-defibrillators”, Journal of Cardiovascular Electrophysiology, 2014 Apr; 25(4): 411-417 

l  Y.-C Liu, C.-S Hung, Y.-W Wu, Y.-C. Lee, Y.-H. Lin, C. Lin, M.-T. Lo, C.-C Chan, H.-P Ma, Y.-L. Ho, C.-H. Chen, Influence of non-alcoholic fatty liver disease on autonomic changes evaluated by the time domain, frequency domain, and symbolic dynamics of heart rate variability. PLoS One, 2013 Apr 23; 8(4): e61803 

l  L.-Y. Lin, M.-T. Lo, P. C.-I. Ko, W.-C. Chiang, C. Lin, K.-H Hsiung, J.-L. Lin , W.-J. Chen and M. H.-M. Ma, A new way to analyze resuscitation quality by reviewing automatic external defibrillator data, Resuscitation, 2012 Feb, 83(2):171-6. 

l  Y.-C. Chang, L.-K. Huon, V.-T. Pham, Y.-J. Chen, S.-F. Jiang, T. T.-F. Shih, T.-T. Tran, Y.-H. Wang, C. Lin, J. Tsao, M.-T. Lo and P-C Wang, "Synchronized imaging and acoustic analysis of the upper airway in patients with sleep-disordered breathing", Physiological Measurement, 2014 Dec; 35(12): 2501-12 


Conference

A.    Invited Speaker

·     “Probing the time-frequency representation of nonlinear and nonstationary signals by Hilbert-Huang transform”, The 2014 Annual meeting of Society of Exploration Geophysicists, Denver, U.S. (2014)

·     “The Use of Signal Analyses of Ventricular Tachycardia Electrograms to Predict the Response of Anti-tachycardia Pacing in Patients with Implantable Cardioverter-Defibrillators” 2015 THRS 1st International Forum of Ventricular Arrhythmia, Taipei, Taiwan (2015)

B.    Oral Presentation

l   “Alterations of circadian rest-activity rhythms in pediatric patients with type-1 narcolepsy during treatment.“ 2016 International Pediatric Sleep Association Congress, Taipei, Taiwan (2016)

l   “Changes of Electroencephalogram with flow limitation during NREM stage II sleep in patients with upper airway resistance syndrome evaluated by a novel respiratory cycle-based analysis.” 2014 Annual Meeting of American Academy of Sleep Medicine, Minneapolis, USA (2014)

l   “Different activation of autonomic nervous system with flow limitation”, The 2013 World Congress on Sleep Medicine, Valencia, Spain (2013)

l   “A new way to analyze resuscitation quality by reviewing automatic external defibrillation data”, The 3rd International Conference on Hilbert-Huang Transform, Qingdao, China (2011)

研究計畫區

· 2014-2017  Realization of a wearable device for biomarker detection and cloud computation based feedback (Subproject 3 :  Exploiting biomarkers of physiological signals recorded from wearable devices by using adaptive data analysis) 

· 2014-2016  Industrial Technology Development Program- Smart Health Care Wearable Devices with Soft Screen (Subproject: Developing wearable vital sign monitoring and extracting the precursors of cardiovascular diseases)

· 2015 Infinitus Inc. (Hong Kong) – Qi index as an approximate of neural-regulated immunity derived from wearable ECG devices. 

· 2016 Flow Inc.- Using the dynamical biomarkers of multiple physiological signals as a surrogate for minor allergic reaction. 

· 2017 Industry-Academy cooperation project of Hsinchu Science Park Bureau-“An integrated platform for early screening of sleep breathing disorders.” 

· 2017 Joint Project of National Central University and Landseed Hospital-Exploring the associations among in-patient longitudinal changes of vital signs, laboratory data of acute exacerbations of chronic obstructive pulmonary disease and their prognosis by machine learning.” 


專利區
  • Method and system for extracting ventricular fibrillation signals in electrocardiogram  using  spline interpolation with uniform phase ensembles US 9451898 B2 Sep, 2016
  • System and method for quantitative analysis of respiratory sinus arrhythmia US 9380948 B1 Jul, 2016
  • Method and system for extracting ventricular fibrillation signals in electrocardiogram, US 9259167 B2 Feb, 2016