專任教師-系統生物與生物資訊組   首頁 師資介紹 專任教師-系統生物與生物資訊組
蘇立仁 副教授 Li-Jen Su
從聘系所:
專線電話:03-4227151轉36111
傳真電話:
E-mail :sulijen@gmail.com
學經歷
Education
2000-2006          Ph.D., Graduate Institute of Life Sciences, NDMC, Taiwan.
1998-2000           M.S., Graduate Institute of Basic Medical Science, CGU, Taiwan.
1989-1992            B.S., School of Pharmacy, Taipei Medical University, Taiwan.
 
Professional Career 
2013-present       Member, The Society of Chinese Natural Medicine.
2012-present       Director,  Core Facilities for High Throughput Experimental Analysis of SyBBi, NCU, Taiwan.   
2012-present       Member, Taiwan Genomic Medicine and Biomarker Society.
2011-present        Assistant Professor, Institute of Systems Biology and Bioinformatics, NCU, Taiwan.
1998-present       Member,  The Chinese Society of Cell and Molecular Biology.
2010-2011            Postdoctoral Scholar, National Science Council, Taiwan. 
2009-2010            Postdoctoral Fellow, Institute of Systems Biology and Bioinformatics, NCU, Taiwan.
2006-2008           Postdoctoral Fellow, Division of Thoracic Surgery, Department of Surgery, VGHTPE, Taiwan. 
 
Other Career https://sites.google.com/site/mdxtlab/heart-chan
2012-present        Director, World Leadership Education Foundation (財團法人世界領袖教育基金會  董事)
2009-present       Consultant, Taiwan Woman and Child Health Promoting Association (社團法人婦幼健康促進協會  專業諮詢委員召集人)
2008-2012            Computation Manager, 3L Parienting and Family Supporting Center
2006-2013            Associate Director, Truth-Virtue-Beauty Chinese Medical Clinic 
1995-1998             Director, I-Sin-Tang Chinese Pharmacy Store 
論文著作區

Journal Publications


2013-present


Tseng AH, Yang JC, Chen CH, Chen CH, Hsu SL, Lee MH, Lee HC* and Su LJ*.

An in vivo Molecular Response Analysis of Colorectal Cancer Treated with  Astragalus membranaceus Extract.

Oncology Reports.  2016; 35 (2): 659-668. http://www.sciencedirect.com/science/article/pii/S0898656814003180#

*These authors contributed equally.


Liu CC, Su LJ, Tsai WY, Sun HL, Lee HC and Wong CS.

Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: association with upregulated expression of the circardian gene NPAS2.

Life Sciences. 2015; 141: 20-24.


Chen CH, Chang AY, Li SH, Tsai HT, Shiu LY, Su LJ, Wang WL, Chiu TJ, Luo SD, Huang TL, Chien CY.

Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer.
Molecular Cancer. 2015; 14(1): 83. [SCI: 5.397; Rank: 29/203 in ONCOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#


Huang HL, Wu CY, Su LJ, Huang YJ, Charoenkwan P, Chen WL, Lee HC, Chu CCW and Ho SY.
Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival data.
BMC Bioinformatics. 2015; 16: 54 [SCI: 2.672; Rank: 8/52 in MATHEMATICAL & COMPUTATIONAL BIOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#

Chen CH, Hsu CL, Huang SH, Chen SY, Hung YL, Chen HR, Wu YC, Su LJ* and Lee HC*.
Method Designed to Respect Molecular Heterogeneity Can Profoundly Correct Present Data Interpretations for Genome-Wide Expression Analysis.
PLoS ONE. 2015; 10(3): e0121154. [SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES ; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#
*These authors contributed equally.

Wei TY*, Hsia JY*, Chiu SC*, Su LJ*, Juan CC*, Lee YC*, Chen JM*, Chou HY, Huang JY, Huang HM, Yu CT. 
Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
Cellular Signalling. 2014; 26(12): 2940-2950.  [SCI: 4.471; Rank: 63/185 in CELL BIOLOGY; Time cited: 0http://www.sciencedirect.com/science/article/pii/S0898656814003180#*These authors contributed equally.
Cheng TM, Liu YR, Wu MH, Chang CC, Shieh DB,  Su LJ, and Yen Y. 
Carcinoembryonic cell adhesion molecule 6 as a therapeutic target for breast cancer. 
The FASEB Journal. 2014; 28 (1 Supplement): 1048.2 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Chiang KC, Yeh CN, Lin KJ, Su LJ, Yen TC, Pang JHS, Kittaka A, Sun CC, Chen MF,Jan YY, Chen TC, Juang HH and  Yeh TS
Chemopreventive and Chemotherapeutic Effect of Dietary Supplementation of Vitamin D on Cholangiocarcinoma in a Chemical-Induced Animal Model.
Oncotarget. 2014; 5 (11): 3849-61. [SCI: 6.636; Rank: 21/197 in ONCOLOGY; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Chien CY, Tsai HT, Su LJ, Chuang HC, Shiu LY, Huang CC, Fang FM, Yu CC, Su HT, and Chen CH. 
Aurora-A signaling is activated in advanced stage of squamous cell carcinoma of head and neck cancer and requires osteopontin to stimulate invasive behavior. 
Oncotarget. 2014; 5(8): 2243-2262. [SCI: 6.636; Rank: 21/197 in ONCOLOGY; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218

Hwang CF, Shiu LY, Su LJ, Yin YF, Wang WS, Huang SC, Chiu TJ, Haung CC, Zhen YY, Tsai HT, Fang FM, Huang TL and Chen CH.

Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis.

PLoS ONE. 2013; 8(12): e84218[SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES; Time cited: 0http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084218


Su LJ, Chang CC, Yang CH, Hsieh SJ, Wu YC, Lai JM, Tseng TL, Huang CYF and Hsu SL. 

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro.

PLoS ONE. 2013; 8(1): e53988.  [SCI: 3.534; Rank: 8/55 in MULTIDISCIPLINARY SCIENCES; Time cited: 0] 


Chen CH, Chuang, HC, Huang CC, Fang FM, Huang HY, Tasi HT, Su LJ, Shiu LY, Leu S, and Chien CY. 

Overexpression of Rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A modulation. 

American Journal of Pathology. 2013; 182(2): 516-528. [SCI: 4.890; Rank: 6/79 in PATHOLOGY; Time cited: 0


 2008-2012


Chiang KC, Yeh CN, Chen SC, Shen SC, Hsu JT, Yeh TS, Pang JHS, Su LJ, Takano M, Kittaka A, Juang HH and Chen TC.

MART-10, a new generation of vitamin D analog, is more potent than 1a,25-dihydroxyvitamin D3 in inhibiting cell proliferation and inducing apoptosis in ER+ MCF-7 breast cancer cells.

Evidence-Based Complementary and Alternative Medicine. 2012; 2012: 310872[SCI: 4.774; Rank: 1/22 in INTEGRATIVE & COMPLEMENTARY MEDICINE; Time cited: 0] 


Kuo YL, Chang PMH, Liu YM, Chen PH, Lee PY, Liu RS, Lai JM, Tien YJ, Wu YC, Su LJ, Kao CY, Chen CH and Huang CYF. 

In silico therapeutic drug screening for reversing the lung adenocarcinoma overexpressed gene signatures. 

Journal of Cancer Science & Therapy. 2012; 1: 101. [SCI: 5.620; Rank: --; Time cited: 0]  doi: 10.4172/scientificreports.101.


Wei TYW*, Juan CC*, Hsia JY*, Su LJ*, Lee YCG*, Chou HY, Chen JMM, Wu YC, Chiu SC, Hsu CP, Liu KL and Yu CTR. 

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

Cancer Science. 2012; 103(9): 1640-50. [SCI: 3.325; Rank: 67/194 in ONCOLOGY; Time cited: 1] 

*These authors contributed equally. 


Chen CH, Shiu LY, Su LJ, Huang CYF, Huang SC, Huang CC, Yin YF, Wang WS, Tsai HT, Fang FM, Chuang WC, Kang HC and Hwang CF.

FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes tonasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway

Journal of Translational Medicine. 2012; 10: 93. [SCI: 3.474; Rank: 31/111 in MEDICINE, RESEARCH & EXPERIMENTAL; Time cited: 0] 


Su LJ, Yang CH, Huang SF, Yuo YL, Hsieh HC, Tseng TL, Chen CH, Hsu SL and Huang CY. 

Evaluation of the Chinese medicinal herb, Graptopetalum paraguayense, as a therapeutic treatment for liver damage in rat models. 

Evidence-Based Complementary and Alternative Medicine. 2012; 2012: 256561. [SCI: 2.175; Rank: 1/22 in INTEGRATIVE & COMPLEMENTARY MEDICINE; Time cited: 0]  doi: 10.1155/2012/256561.


Su LJ*, Wu LC and Tseng ALH. 

Comparison of mRNA Gene Expression Analysis between Quantitative-real time PCR Assay and DNA Microarray Based Assay. 

Adv Biomed Eng. 2011; 3-5: 158-67 [EI; Time cited: 0] (ISSN: 2160-0589, ISSN/ISO: Advances in Biomedical Engineering

*First and corresponding author. 


Yu CT, Hsia JY, Hseih YC, Su LJ, Lee TC, Ku CF, Chen KS, Maureen Chen JM, Wade Wei TY, Lee YC, Huang CY, Wu YC, Yang CY and Hsu SL. 

The Novel Protein Suppressed in Lung Cancer Down-Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A. 

Journal of Thoracic Oncology. 2011; 6(6): 988-997.  [SCI: 3.661; Rank: 9/48 in RESPIRATORY SYSTEM; Time cited: 0

 

Hwang CF, Chien CY, Huang SC, Yin YF, Huang CC, Fang FM, Tsai HT, Su LJ, and Chen CH. 

Fibulin-3 is associated with tumor progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity. 

The Journal of Pathology. 2010; 222(4):367-79. [SCI: 6.318;  Rank: 3/78 in PATHOLOGY; Time cited: 7 [PDF]

 
Wu YC*, Su LJ*, Wang HW, Lin CFJ, Hsu WH, Chou, TY, Perng, DW, Wang, LS, and Hsueh CT. 
Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. 
Journal of Thoracic Oncology. 2010; 5(8): 1167-1174. [SCI: 3.661; Rank: 9/48 in RESPIRATORY SYSTEM; Time cited: 4 [PDF]
*These authors contributed equally. 
 
Chen CH, Lai JM, Chou TY, Chen CY, Cheng TS, Su LJ, Whang-Peng J, Chou CK, Wu YC, and Huang CYF. 
VEGF-A upregulates FLJ10540 expression and modulates migration and invasion of lung cancer cells via PI3K/AKT pathway. 
PLoS ONE. 2009; 4(4): e5052. [SCI: 4.092; Rank: 12/84 in BIOLOGY; Time cited: 16 [PDF]
 
Wong FH*, Huang CYF*, Su LJ*, Wu YC, Lin YS, Hsia JY, Tsai HT, Lee SA, Lin CH, Chen PM, Chen YJ, Liang SC, Lai JM, and Yen CC. 
Microarray profiling delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. 
International Journal of Oncology. 2009; 34(1): 117-28. [SCI: 2.399; Rank: 108/194 in ONCOLOGY; Time cited: 13 [PDF]
*These authors contributed equally. 

2003-2007
 
Su LJ, Chang CW, Lin CJ, Wu YC, Chen CH, Liang SC, Lin CH, Chen KC, Whang-Peng J, and Huang CYF. 
Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme. 
BMC Genomics. 2007; 8: 140. [SCI: 4.073; Rank: 26/157 in  BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 62 [PDF]
 
Hsu CN, Lai JM, Liu CH, Tseng HH, Lin CY, Lin KT, Yeh HH, Sung TY, Hsu WL, Su LJ, Lee SA, Chen CH, Lee GC, Lee DT, Shiue YL, Yeh CW, Chang CH, Kao CY, and Huang CY. 
Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online). 
BMC Bioinformatics. 2007; 8: 66. [SCI: 2.751; Rank: 6/47 in MATHEMATICAL & COMPUTATIONAL BIOLOGY; Time cited: 19[PDF]
 
Su LJ, Hsu SL, Yang JS, Tseng HH, Huang SF, and Huang CY. 
Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis. 
Gene Expression. 2006;13(2): 107-32. [SCI: 1.308; Rank: 111/157 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 8[PDF]
 
Su LJ*, Lin YS*, Yu CT*, Wong FH*, Yeh HH, Chen SL, Wu JC, Lin WJ, Shiue YL, Liu HS, Hsu SL, Lai JM, and Huang CY. 
Gene expression profiles of the aurora family kinases. 
Gene Expression. 2006; 13(1): 15-26. [SCI: 1.308; Rank: 111/157 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Time cited: 25] [PDF]
*These authors contributed equally. 
 
Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, and Huang CY. 
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. 
Molecular & Cellular Proteomics. 2004; 3(1): 93-104. [ SCI: 7.398; Rank: 5/72 in BIOCHEMICAL RESEARCH METHODS; Time cited: 23[PDF]
 
Chao CC, Su LJ, Sun NK, Ju YT, Lih JC, and Lin-Chao S. 
Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. 
Journal of Neuroscience Research. 2003; 74(2): 248-54. [ SCI: 2.738; Rank: 123/243 in  NEUROSCIENCES; Time cited: 12[PDF]
2011 JCR Science Edition 
研究計畫區

Two candidate drugs, BP002 and BP004, for medical applications of colorectal cancer.「從藥物BP002BP004的開發到大腸癌醫學之應用」NSC (2015/08-2016/07) [104-2320-B-008 -004]; PI

 

Identification of genes related to metastasis and their regulating mechanisms in lung cancer by combination of pathological subtypes and gene expression in microarray.「結合肺癌之病理分型與微陣列分析以找出與轉移相關之基因及其調控機轉研究」NSC (2015/08-2016/07) [104-2314-B-075 -062]; co-PI

 

Integrative approaches for drug development in triple negative type of breast cancer. 「三陰型乳癌藥物開發之解決策略」臺北市政府衛生局統籌款自行研究計畫 (2015/01-2015/12) [10401-62-057]; co-PI

 

Perfluorinated Compounds, Fertility, and Epigenetic Transgenerational Inheritance: Animal and Prospective Follow-up Studies.「全氟碳化物、生育及跨世代外遺傳機制探討:動物及前瞻追蹤性研究」 (2013/08-2016/07) [NSC 102-2314-B-002-116-MY3]; co-PI

 

Total solution of integrative approaches from pathological classification, drug development to medical application in lung cancer.「從肺癌的病理分類、藥物開發到醫學應用之整體解決策略」 (2013/08-2016/07) [NSC 102-2628-B-075-003-MY3]; co-PI

 

An Integrated Approach for the Prediction, Screening and Validation of Systems Therapeutic Candidates for Colorectal Cancer.「系統性治療大腸直腸癌症之候選藥物預測、篩選與驗證的整合性策略」NSC (2012/08-2015/07) [NSC 101-2320-B-008-001-MY3]; PI

 

Validation of of NCU-BP001 as a therapeutic candidate and mechanisms involved for type 2 diabetes.「驗證NCU-BP001 中草植物藥成分對第二型糖尿病之療效與生效機制」102年度中大國防醫聯合研發中心計畫 (2013/01-2013/12) [102NCU-NDMC-5]; PI

 

Total solution of integrative approaches from drug development to medical application in breast cancer.「從乳癌的藥物開發到醫學應用之整體解決策略」102年度國立中央大學暨壢新醫院 聯合研發計畫 (2013/01-2013/12) [NCU-LSH-102-A-011]; PI

 

The use of cell biology, system biology and high- throughout screening platform for the study of anti-hepatitis effect of the herbal medicines and natural active products.「利用細胞生物學、系統生物學與高速篩選平台進行中草藥與活性天然物之抗肝臟發炎作用之研究」臺北市政府衛生局統籌款自行研究計畫 (2013/01-2013/12) [101XDAA00005; 10201-62-020]; co-PI

 

Gene expression integration to delineate the molecular basis of clinical diagnosis markers in non-small-cell lung cancer by systems biology approach. 「藉助系統生物學分析基因表現圖譜描述臨床診斷相關的標記和預測非小細胞肺癌病患效果評估」 NSC (2011/08-2013/07) [NSC 100-2314-B-075-004-MY2]; co-PI

 

Gene expression integration to delineate the molecular basis of breast cancer progression associated genes and chemotherapeutic targets by integrated array system approach. 「 藉助多重微陣列整合系統研究乳癌相關基因表現之圖譜探討乳癌病變及治療之標靶分子」 101年度國立中央大學暨壢新醫院 聯合研發計畫 (2012/01-2012/12) [NCU-LSH-101-A-008]; PI

 

Genome-wide expression profiling to delineate the molecular basis of post-traumatic osteoarthritis progression associated genes.「創傷後膝關節炎進程相關基因之探討基因體表現圖譜分析」101年度國立中央大學暨國泰綜合醫院 聯合研發計畫 (2012/01-2012/12) [101CGH-NCU-B4]; co-PI

 

中央大學100學年度「新進教師及研究人員學術研究經費補助」(2012/01-2012/12) [100G099-8]; PI

 

Gene expression integration to delineate the molecular basis of disease associated genes and drug development by integrated array system approach. NSC (2010/08-2011/07) [NSC 99-2112-M-008-012] ; [ NSC 99-2811-M-008-053]; PI

Gene expression integration to delineate the molecular basis of COX-2 and mPGES1 associated genes in non-small-cell lung cancer by integrated array system approach. VGHTPE (2011/01-2011/12) [V100C-160]; co-PI

 

Identification of therapeutic targets for lung adenocarcinoma by functional genomics. NRPGM (2008/04-2009/03) [NSC 97-3112-B-075-001]

 

Identification of therapeutic targets for lung adenocarcinoma by functional genomics. NRPGM (2007/04-2008/04) [NSC 96-3112-B-075-001]

 

Identification of therapeutic targets for lung adenocarcinoma by functional genomics. NRPGM (2006/04-2007/03) [NSC 95-3112-B-075-002]

專利區
陳志浩 (Chih-Hao Chen)、李弘謙 (H.C. Lee)、蘇立仁 (Li-Jen Su)"實施於計算機的差異表現基因辨認方法以及此方法之電腦可讀取記錄媒體" (Computer-implemented method for identifying deferentially expressed genes and computer readable storage medium for storing the method)。
台灣發明第 I 472944 號專利權, 2015.02.11, (2015/02-2032/12)。

https://sites.google.com/site/mdxtlab/princirpal-investigator/%E6%8E%83%E6%8F%8F.jpg?attredirects=0


謝惠珠 (Hui-Chu Hsieh)、曾錙翎 (Tzu-Ling Tseng)、蘇立仁 (Li-Jen Su)、黃奇英 (Chi-Ying Huang)、徐士蘭 (Shih-Lan Hsu) 
“肝纖維化及/或肝硬化之生物標誌及其檢驗方法” (Biomarkers for liver fibrotic injury) 。
美國發明第7,972,785 號專利權, 2011.07.05, (2011/07-2023/12)。 
新加坡發明第 134283 號專利權, 2009.11.30, (2009/11-2027/01)。
日本發明第 4297942 號專利權, 2009.04.24, (平成21年04月24日), (2009/04-2027/01) 。