專任教師-生物醫學工程組   首頁 師資介紹 專任教師-生物醫學工程組
李宇翔 副教授 Yu Hsiang Lee
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學經歷
2014 - Now-----Associate Professor
2010 - 2014----Assistant Professor
2008 - 2010----Postdoctoral Fellow, UCLA Dental Research Institute (USA)
2006 - 2008----Research Scientist I, Sierra Sciences LLC (USA)
2006-------------Ph.D. Dept. of Chemical Engineering, University of Southern California (USA)
論文著作區

Selected Journal paper (*Corresponding author)


[1]    Lee Y-H*, Ma Y-T. (2017/05) Synthesis, characterization, and biological verification of anti-HER2 indocyanine green-doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells. Journal of Nanobiotechnology 15(1): 41 (SCI) (MOST 105-2221-E-008-014)

[2]    Lee Y-H*, Chang D-S. (2017/04) Fabrication, characterization, and biological evaluation of anti-HER2 indocyanine green-doxorubicin-encapsulated PEG-b-PLGA copolymeric nanoparticles for targeted photochemotherapy of breast cancer cells. Scientific Reports 7: 46688 (SCI) (MOST 105-2221-E-008-014) (105CGH-NCU-A2).

[3]    Lee Y-H*, Li P-H. (2017/02) Using Resonant Ultrasound Field-Incorporated Dynamic Photobioreactor System to Enhance Medium Replacement Process for Concentrated Microalgae Cultivation in Continuous Mode. Chemical Engineering Research and Design 118(2017): 112-120 (SCI/EI) (MOST 105-2221-E-008-014) (105CGH-NCU-A2).

[4]    Lee Y-H*, Lai Y-H. (2016/12) Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells. PLOS ONE 11(12): e0168192 (SCI) (MOST 105-2221-E-008-014)

[5]    Lee Y-H*, Lee C-C, Huang C-H, and Ho F-M*. (2016/08) Laminar Shear Stress Promotes Nicotine-Induced Inflammation and Hemostatic Expression in Human Endothelial Cells. Cellular and Molecular Bioengineering 9(3): 466-477 (SCI) (MOST 104-2221-E-008-095).

[6]    Lee Y-H*, Lai Y-H. (2015/09) Fabrication and Characterization of HER2 Cell Receptor-Targeted Indocyanine Green-Encapsulated Poly(Lactic-co-Glycolic Acid) Nanoparticles. Peertechz Journal of Biomedical Engineering 1(1): 015-020. (MOST 104-2221-E-008-095).

[7]    Lee Y-H, Chen R-S, Chang N-C, Lee K-R, Huang C-T, Huang Y-C, and Ho F-M*. (2015/09) Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells. Annals of Biomedical Engineering 43(9): 2220-2230. (SCI/EI) (NSC 101-2221-E-008-018)

[8]    Lee Y-H*, Wu Z-Y. (2015/08) Enhancing Macrophage Drug Delivery Efficiency via Co-Localization of Cells and Drug-Loaded Microcarriers in 3D Resonant Ultrasound Field. PLOS ONE 10(8): e0135321. (SCI) (104CGH-NCU-A1)

[9]    Lee Y-H*, Yeh Y-L. (2015/07) Reduction of Oxygen Inhibition Effect for Microalgal Growth Using Fluoroalkylated Methoxy Polyethylene Glycol-Stabilized Perfluorocarbon Nano-Oxygen Carriers. Process Biochemistry 50(7): 1119-1127. (SCI) (NSC 101-2622-E-008-014-CC3). (Highlighted Article)

[10]   Lee Y-H*, Yeh Y-L. (2014/08) Using polyethylene glycol as nonionic osmoticum to promote growth and lipid  production of marine microalgae Nannochloropsis oculata. Bioprocess and Biosystems Engineering 37(8): 1669-  1677. (SCI/EI) (NSC 101-2622-E-008-014-CC3)

[11]   Lee Y-H*, Yeh Y-L, Lin K-H, and Hsu Y-C. (2013/08) Using Fluorochemical as Oxygen Carrier to Enhance the    Growth of Marine Microalga Nannochloropsis oculata. Bioprocess and Biosystems Engineering 36(8): 1071-  1078. (SCI/EI) (NSC 100-2622-E-008-013-CC3

[12]   Lee Y-H*, Tseng C-S, and Wei Y-L. (2012/11) Fabrication and Characterization of CdSe/ZnS Quantum Dots-  Doped Polystyrene Microspheres Prepared by Self-Assembly. Journal of Materials Research 27(22): 2829-2836.  (SCI/EI)

[13]   Lee Y-H, Joshipura K, Vergara JL, and Wong DT*. (2012/03-06) Detection of Type II Diabetes Mellitus Using    Salivary Transcriptomic Biomarkers. Genomic Medicine, Biomarkers and Health Sciences 4: 7-11. (SCOPUS)

[14]   Lee Y-H, Kim JH, Zhou H, Kim BW, Wong DT*. (2012/04) Salivary transcriptomic biomarkers for detection of  ovarian cancer: For serous papillary adenocarcinoma. Journal of Molecular Medicine 90(4): 427-434. (SCI)

[15]   Lee Y-H, Zhou H, Reiss JK, Yan X, Zhang L, Chia D, and Wong DTW*. (2011/09) Direct Saliva Transcriptome  Analysis. Clinical Chemistry 57(9): 1295-1302 (SCI)

[16]   Lee Y-H, Peng C-A*. (2009/12) Effect of hypotonic stress on retroviral transduction. Biochemical and  Biophysical Research Communications 390(4) 1367-1371. (SCI)

[17]   Lee Y-H, Wong DT*. (2009/08) Saliva: An emerging biofluid for early detection of diseases. American Journal  of Dentistry 22(4): 241-248. (SCI)

[18]   Lee Y-H, Peng C-A*. (2007/05) Nonviral Transfection of Suspension Cells in Ultrasound Standing Wave  Fields. Ultrasound in Medicine and Biology 33(5): 734-742. (SCI/EI)

[19]   Lee Y-H, Lai C-Y, Li P-C, Peng C-A*. (2005/12) Ultrasound-Mediated Perfluorocarbon Microbubbles Bursting    for Gene Transfection. Journal of Medical and Biological Engineering 25(4): 153-158. (SCI/EI).

[20]   Lee Y-H, You J-O, Peng C-A*. (2005/03-04) Retroviral transduction of adherent cells in resonant acoustic  fields. Biotechnology Progress 21(2): 372-376. (SCI/EI)

[21]   Lee Y-H, Peng C-A*. (2005/04) Enhanced retroviral gene delivery in ultrasonic standing wave fields. Gene Therapy 12(7): 625-633 (SCI)



研究計畫區

年度

補助類別

合作企業

計畫起迄年月

計畫名稱

擔任之工作

執行情形

100

專題研究計畫

(產學合作研究計畫-應用型)

索瑪沛思生物科技股份有限公司

06/01/2011- 05/31/2012

研究開發以碳氟化物促進氣體交換之生物反應器

(NSC 100-2622-E-008-013-CC3)

主持人

已結案

101

專題研究計畫

(新進人員)

---

08/01/2012- 07/31/2013

以層流剪力系統探討菸鹼與血管內皮細胞病變之相關聯性

(NSC 101-2221-E-008-018-)

主持人

已結案

101

專題研究計畫

(產學合作研究計畫-應用型)

索瑪沛思生物科技股份有限公司

11/01/2012- 10/31/2013

以含氟素界面活性劑製備全氟碳化物乳膠微粒用於光生物反應器中以增進系統氣體交換率之研究

(NSC 101-2622-E-008 -014 -CC3)

主持人

已結案

102

專題研究計畫

(新進人員)

---

08/01/2013- 07/31/2014

以層流剪力系統探討菸鹼與血管內皮細胞病變之相關聯性(II)

(NSC 102-2221-E-008 -012 -)

主持人

已結案

104

專題研究計畫

(一般型)

---

08/01/2015-07/31/2016

包覆ICG與阿黴素之標靶全氟碳奈米乳劑研製於強化乳癌螢光擴散光學影像暨光/化學治療之研究

(MOST 104-2221-E-008-095-)

主持人

已結案

105

專題研究計畫

(一般型)

---

2016/08/01- 2017/07/31

包覆ICG與阿黴素之標靶全氟碳奈米乳劑研製於強化乳癌螢光擴散光學影像 暨光/化學治療之研究(II) (III) (MOST 105-2221-E-008 -014 -)

主持人

執行中

105

專題研究計畫

(一般型)

---

2016/08/01- 2017/07/31

螢光擴散光學斷層造影系統研製與校正(II)

(MOST 105-2221-E-008 -045 -)

共同主持人

執行中

106

專題研究計畫(產學合作研究計畫-開發型)

宇格材料企業有限公司

2017/02/01- 2018/01/31

設計開發一新型節能之駐波聲場光生物反應器系統用以提升微藻養殖之效能
(MOST 106-2622-E-008 -011 -CC2)

主持人

執行中

106

專題研究計畫

(一般型)

---

2017/08/01- 2018/07/31

螢光擴散光學斷層造影系統研製與校正(III)  

(MOST 106-2221-E-008 -046 -)

共同主持人

執行中

106

專題研究計畫

(一般型)

---

2017/08/01- 2018/07/31

研製包覆靛氰綠與絲裂黴素C之標靶全氟碳奈米乳劑應用於膀胱癌光-化學治療之研究

(MOST 106-2221-E-008-060-)

主持人

執行中

專利區

[1]      李宇翔,葉昱伶。培養擬球藻之系統。中華民國專利 發明第I 487481號。(2015-2033)

[2]      李宇翔,馬韻婷。藥物丸粒、其醫藥組合物及其用途。經濟部智慧財產局審查案號:105134788,申請日: 20161027日,審查中