專任教師-生物醫學工程組   首頁 師資介紹 專任教師-生物醫學工程組
黃俊銘 生醫講座教授 Eric Chun-Ming Huang
從聘系所:
專線電話:03-4227151轉36101
傳真電話:03-4253427
個人網站:
學經歷
學 歷:
(B.S.) National Taiwan University, Taipei, Dept. of Zoology, 1990
(Ph. D.)National Taiwan University, Taipei, Inst. Of Zoology, 1995
經 歷:
Fred Hutchinson Cancer Research Center, Seattle, Washington (博士後研究, Molecular Biology)(1995-1996)
Institute of Biomedical Sciences, Academia Sinica, Taipei (博士後研究, Biochemistry)(1996-1998)
Institute of Biological Chemistry, Academia Sinica, Taipei (博士後研究, Proteomics)(1998-2000)
(2000-2001) Assistant Professor, Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan
(2001-2002) Research Scientist, Vaxin, Inc., Birmingham, Alabama
(2002-2005) Assistant Professor, Department of Dermatology, The University of Alabama at Birmingham, Birmingham, Alabama
(2004-2005) Assistant Professor. Co-appointment, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama

(2004-2005) Co-director, Skin Proteomics Core of UAB Skin Disease Research Center

(2005-2007) Associate Professor, La Jolla Institute for Molecular Medicine, San Diego, California

(2006-2009) Research Scientist, Co-appointment, Veterans Medical Research Foundation of San Diego
(2007-) Associate Member, Moores Cancer Center, University of California, San Diego
(2006-2011) Associate Professor, Division of Dermatology, School of Medicine, University of California, San Diego, CA

(2013-) Visiting Professor, Institutes of Biomedical Sciences &Shanghai Public Health Clinical Center, Fudan University

(2014-) Visiting Professor, Chengdu Second People’s Hospital

(2011-2014) Professor, Department of Dermatology, School of Medicine, University of California, San Diego, CA
(2014-present) Adjunct Professor, Department of Dermatology, School of Medicine, University of California, San Diego, CA

(2014-present) Chair Professor, Department of Biomedical Sciences and Engineering, National Central University, Taiwan


Other Experience and Professional Memberships
(2000) Allowance of the U.S. patent “Use of Somatostatin Analogs For the Delivery of Anti-Tumor Drugs to Tumor Cells” (Serial No: 09/734,298, Filed: December 11,2000 )
(2000) Allowance of the U.S. patent “New Anti-liver Disease Drug R-YEEE and Method of Synthesizing Branched Galactose-Terminal Glycoproteins.” (Serial No:09/490,734. Filing Date: January 25, 2000)
(2007) Editorial board: The Open Proteomics Journal; Current Proteomics; Genomics Insights.
(2008) Guest Editors: Infectious Diseases- Drug Targets; Current Drug Metabolism
(2009) Allowance of the U.S. patent (858610-2006.1) “Novel Targets And Compositions For Use In Decontamination, Immunoprophylaxis, And Post-Exposure Therapy Against Anthrax.” (Serial No:10/889,197497. Filing Date: July 12, 2004)
(2010) International Publication Number (WO 2010/065735) “METHODS AND COMPOSITIONS FOR TREATING P.ACNES”. International Publication Date: 06, June, 2010.
(2011) International Publication Number (WO 2010/065735) licensed to Sanofi-Pasteur.
(2014) Provisional patents (case no 2012-318) “Skin Commensal Bacterial Fermentation as Probiotics for Promoting Skin Health” and (case no 2013-036) “Acne Probiotics” licensed to Dermala Inc.
Honors
(2009) Research Grant Award, Dermatology Foundation/USA; 2009 Galderma International Award

論文著作區
B. Selected peer-reviewed publications:
*1. Wang, Y., Tissa, R.H., Tong, Y.L., Kao, M.S., Zouboulis, C.C., Gallo, R.L., and Huang, C.-M. The anti-inflammatory activities of Propionibacterium acnes CAMP factor-targeted acne vaccines. J. Invest Dermatol, 2018, Jun 28. pii: S0022-202X(18)32228-0.
*2. Yang, J.J., Chang, T.W., Jiang, Y., Kao, H.J., Chiou, B.H., Kao, M.S., and Huang, C.-M. Commensal Staphylococcus aureus Provokes Immunity to Protect against Skin Infection of Methicillin-Resistant Staphylococcus aureus. Int J Mol Sci. 2018, 19(5).
*3. Liu, P.F., Wang, Y., Simmons, C.W., Ulrich, R.G., Gallo, R.L., VanderGheynst, J.S., and Huang, C.-M. Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. J of Immunology Research, 2018, 3710961.
*4. Liu, P.F., Wang, Y., Liu, Y.T., and Huang, C.-M. Vaccination with Killed but Metabolically Active E. coli Over-expressing Hemagglutinin Elicits Neutralizing Antibodies to H1N1 Swine Origin Influenza A Virus. J Nat Sci, 2017, 3(2):e317.
*5. Kao, M.S., Huang, S., Chang, W.L., Hsieh, M.F., Huang, C.J., Gallo, R.L., Huang, C.-M. Microbiome precision editing: Using PEG as a selective fermentation initiator against methicillin-resistant Staphylococcus aureus. Biotechnology Journal, 2017 Apr;12(4). doi: 10.1002/biot.201600399. Epub 2017 Feb 8.
6. Hsu, P.C., Chiou, B.H., and Huang, C.-M. Bioinformatics approach reveals the gene targets of Ebola virus microRNAs involved in the human skin microbiome. Peer J, 2017, https://doi.org/10.7287/peerj.preprints.2959v1
*7. Wang, Y., Zhang, L., Yu, J., Huang, S., Wang, Z., Chun, K.A., Lee, T.L., Chen, Y.T., Gallo, L.R., and Huang, C.-M. A Co-drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation. J. Invest Dermatol, 2016, S0022-202X(16)32239-4.
*8. Chen, H.W., Liu, P.F., Liu, Y.T., Kou, S., Zhang, X.Q., Schooley, R.T., Rohde, H., Gallo, R.L., Huang, C.-M. Nasal commensal S. epidermidis bacteria counteract influenza virus. Scientific Reports, 2016 Jun 16;6:27870. doi: 10.1038/srep27870.
9. Sanford, J.A., Zhang, L.J., Williams, M.R., Gangoiti, J.A., Huang, C.-M., Gallo, R.L. Inhibition of HDAC8 and HDAC9 by microbial short chain fatty acids breaks immune tolerance of the epidermis to TLR ligands. Science Immunology, 2016, eaah 4609.
*10. Wang Y, Kao MS, Yu J, Huang S, Marito S, Gallo RL, Huang, C.-M. A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes. Int J Mol Sci. 2016,17(11). pii: E1870.
*11. Liu, P.F., Cheng, J.S., Sy, C.L., Huang, W.C., Yang, H.C., Gallo, R.L., Huang, C.-M*, Shu, C.W. IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus. J Invest Dermatol. 2015, 135(11):2714-22. *shared correspondence.
*12. Kao, M.S., Wang, Y., Marito, S., Huang, S., Lin, W.Z., Gangoiti, J.A., Barshop, B.A., Hyun, C., Lee, W.R., Sanford, J.A., Gallo, R.L., Ran, Y., Chen, W.T., Huang, C.J., Hsieh, M.F., Huang, C.-M. The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome, Journal of Microbial& Biochemical Technology, 2016 Aug;8(4):259-265.
13. Tran, T.Q.M., Hsieh, M.F., Chang, K.L., Pho, Q.H., Nguyen, C.Y., and Huang, C.-M. Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes. Polymers 2016, 8(9), 321
**14. Liu, P.F., Hsieh, Y.D., Lin, Y.C., Two, A., Shu, C.W., Huang, C.-M. Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris. Curr Drug Metab. 2015;16(4):245-54.
**15. Huang, C.-M. Editorial: Treatments Targeting the Human Microbiomes. Curr Drug Metab. 2015;16(4):244.
*16. Wang, Y., Dai, A., Huang, S., Kuo, S., Shu, M., Tapia, C.P., Yu, J., Two, A., Zhang, H., Gallo, R.L., and Huang, C.-M. Propionic acid and its esterified derivative suppress the growth of methicillin-resistant Staphylococcus aureus USA300. Benef Microbes, 2014, 5(2):161-8.
*17. Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A., Gallo, R.L., and Huang, C.-M. Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. Appl Microbiol Biotechnol, 2014;98(1):411-24
*18. Shu, M, Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R.L., and Huang, C.-M. Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics Against Methicillin-Resistant Staphylococcus aureus. PLoS ONE, 2013;8(2):e55380
19. Pornpattananangkul, D., Fu, V., Thamphiwatana, S., Zhang, L., Chen, M., Vecchio, J., Gao, W., Huang, C.-M., and Zhang, L. In Vivo Treatment of Propionibacterium acnes Infection with Liposomal Lauric Acids. Adv Healthcare Mater, 2013 Mar 12. doi: 10.1002/adhm.201300002. [Epub ahead of print]
*20. Liu, P.F., Shu, C.W., and Huang, C.-M. Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein of Fusobacteria nucleatum. Curr Mol Med. 2013, in press.
*21. Shu, M., Kuo, S., Wang, Y., Jiang, Y., Liu, Y.T., Gallo, R.L., and Huang, C.-M. Porphyrin Metabolisms in Human Skin Commensal Propionibacterium acnes Bacteria: Potential Application to Monitor Human Radiation Risk. Curr Med Chem. 2013;20(4):562-8.
*22. Wang, Y., Zhu, W., Shu, M., Jiang, Y., Gallo, R.L., and Huang, C.-M. The Response of Human Skin Commensal Bacteria as a Reflection of UV Radiation: UV-B Decreases Porphyrin Production. PLoS ONE, 2012;7(10):e47798.
*23. Shu, C.W., Liu, P.F., and Huang, C.-M. High-Throughput Screening for Drug Discovery of Autophagy Modulators. Comb Chem High Throughput Screen. 2012 Nov 1;15(9):721-9.
*24. Zhu, W., Gallo, R.L., and Huang, C.-M. Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry. JoVE, 2012 Aug 7;(66).
*25. Liu, P.F., Nakatsuji, T., Zhu, W., Gallo, R.L., and Huang, C.-M. Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine. 2011 Apr 12;29(17):3230-8. *26. Nakatsuji, T., Tang, D.C., Zhang, L., Gallo, R.L., and Huang, C.-M. Propionibacterium acnes CAMP Factor and Host Acid Sphingomyelinase Contribute to Bacterial Virulence:Potential Targets for Inflammatory Acne Treatment. PLoS ONE, 2011 Apr 12;6(4):e14797. *27. Chen, C.H., Wang, Y., Liu, Y.T., Zouboulis, C.C., Gallo, R.L., Zhang, L., Hsieh, M.F., and and Huang, C.-M. An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine. J Microbiol Biotechnol. 2011 Apr;21(4):391-9.
28. Pornpattananangkul, D., Zhang, L., Olson, S., Aryal, S., Obonyo, M., Vecchio, K., Huang, C.-M., and Zhang, L. Bacterial Toxin-Triggered Drug Release from Gold Nanoparticle-Stabilized Liposomes for the Treatment of Bacterial Infection. J Am Chem Soc. 2011 Mar 23;133(11):4132-9.
29. Chen, C.H., Huang, C.-M., and Hsieh, M.F. Enhancement of Catechin Skin Permeation via a Newly Fabricated mPEG-PCL-graft-2-hydroxycellulose membrane. J Memb Sci., 2011, 371:7. *30. Huang, C.-M., Chen, C.H., Pornpattananangkul, D., Zhang, L., Chan, M., Hsieh, M.F., and Zhang, L. Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids. Biomaterials. 2011, 32(1):214-221.
*31. Lo, C. W., Lai, Y.K., Liu, Y.T., Gallo R.L. and Huang, C.-M. Staphylococcus aureus hijacks a skin commensal to intensify its virulence: Immunization targeting β-hemolysin and CAMP factor. J. Investigative Dermatology, 2011, 131(2):401-9.
*32. Chen, C.H., Zhang, X.Q., Lo, C.W., Liu, P.F., Liu, Y.T., Gallo, R.L., Hsieh, M.F., Schooley, R.T., and Huang, C-M. Proteomics validates the essentiality of alpha-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza A virus. Proteomics, 2010, 10(12):2396-401.
*33. Yen, T., and Huang, C-M. Current status of acne vaccines. Expert Review of Dermatology, 2010, 5(5):561-566. 34. Pornpattananangkul, D., Olson, S., Aryal, S., Sartor, M., Huang, C.-M., Vecchio, K., Zhang, L. Stimuli-Responsive Liposome Fusion Mediated by Gold Nanoparticles. ACS Nano. 2010, 27;4(4):1935-42. *35. Pan, T.L., Wang, P.W., Lee, W.R., Fang, C.L., Chen, C.C., Huang, C.-M., Fang, J.Y. Systematic evaluations of skin damage irradiated by an erbium:YAG laser: histopathologic analysis, proteomic profiles, and cellular response. J Dermatol Sci. 2010, 58(1):8-18.
*36. Liu, P.F., Shi, W., Zhu, W., Smith, J.W., Hsieh, S.L., Gallo, R.L., and Huang, C.-M. Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. Vaccine, 2010, 28(19):3496-505.
37. Chan, A. S., Chen, C.H., Huang, C.-M, Hsieh MF. Regulation of particle morphology of pH-dependent poly(epsilon-caprolactone)-poly(gamma-glutamic acid) micellar nanoparticles to combat breast cancer cells. J Nanosci Nanotechnol. 2010, 10(10):6283-97.
*38. Yang, D., Pornpattananangkul, D., Nakatsuji, T., Chan, M., Carson, D., Huang, C.-M., Zhang, L. The Antimicrobial Activity of Liposomal Lauric Acids Against Propionibacterium acnes, Biomaterials, 2009, 30(30); 6035-6040. *share corresponding authorship
*39. Nakatsuji, T., Kao, M.C., Zhang, L., Zouboulis, C.C., Gallo, R.L., and Huang, C.-M. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating β-defensin-2 expression. J. Investigative Dermatology, 2009, 130(4):985-94.
40. Lai, Y., Nardo, A.D., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A.L., Wu, Z.R., Hooper, L.V., von Aulock, S., Radek, K.A., Huang, C.-M., Ryan, A.F., and Gallo, R.L. Commensal bacteria regulate TLR3-dependent inflammation following skin injury. Nature Medicine, 2009, 15(12):1377-82.
**41. Liu, P.F., Lo, C.W. Chen, C.H., Hsien, M.F., and Huang, C.-M. Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections. Curr Drug Metab., 2009, 10(8):875-84.
*42. Nakatsuji, T., Kao, M.C., Fang, J.Y., Zouboulis, C.C., Zhang, L., Gallo, R.L., and Huang, C.-M. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J. Investigative Dermatology, 2009, 129(10):2480-8.
*43. Zhang L, Pornpattananangku D, Hu CM, Huang, C.-M. Development of Nanoparticles for Antimicrobial Drug Delivery. Curr Med Chem. 2009, 17(6):585-94.
44. Lee, D.Y., Huang, C.-M., Nakatsuji, T., Thiboutot D., Monestier, M., Kang, S.A., Gallo, R.L. Histone H4 is a major component of the antimicrobial action of human sebocytes. J. Investigative Dermatology, 2009,129(10):2489-96.
**45. Kao, M.C. and Huang, C. -M. Acne vaccines targeting Propionibacterium acnes. Giornaleital. Dermat. Venereol. 2009, 144(6):639-43.
*46. Liu, P.F., Kinder Haake, S., Gallo, R.L., and Huang, C.-M. A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis. Vaccine, 2009, 27(10):1589-1595.
47. Pan, T.L., Wang, P.W., Huang, C.-M., Chen, C.C., and Fang, J.Y. Elucidation of percutaneous absorption of chromium compounds by functional proteomic. Proteomics, 2009, 9(22):5120-31..
48. Yusuf, N, Nasti, T.H., Huang, C. -M, Huber, B.S., Jaleel, T., Lin, H.Y., Xu, H., and Elmets, C.A. Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. J. Immunol. 2009,182(1):675-83.
*49. Huang, C.-M. Smith, J.W., and Zhu, W. Mass Spectrometry-Based Label-Free Quantitative Proteomics, J. of Biomedicine and Biotechnology. 2010, 2010:840518.
*50. Cuong NV, Hsieh MF, Huang, C.-M. Recent Development in Nano-sized Dosage Forms of Plant Alkaloid Camptothecin-Derived Drugs. Recent Pat Anticancer Drug Discov. 2009, 4(3):254-61.
*51. Liu, P.F., Zhu, W., and Huang, C. -M. Vaccines and photodynamic therapies for oral microbial-related diseases. Curr Drug Metab., 2009, 10(1):90-93. PMID:19149517.
*52. Huang, C. -M. and Zhu, W. Profiling Human Saliva Endogenous Peptidome via a High-throughput MALDI-TOF-TOF Mass Spectrometry. Comb. Chem. High Throughput Screen, 2009, 12(5):521-31.
*53. Nakatsuji, T., Rasochova, L., and Huang, C. -M. Vaccine therapy for P. acnes-associated diseases. Infect Disord Drug Targets., 2008, 8(3):160-165. PMID: 18782033
*54. Huang, C. -M. Metabolism of drugs targeting microbiome. Curr Drug Metab., 2009, 10(1):1.
*55. Nakatsuji, T., Shi, Y., Zhu, W., Huang, C.P., Chen, Y.R., Lee, D.Y., Smith, J.W., Gallo, R.L., and Huang, C. -M. Bioengineering a Humanized Acne Microenvironment Model: Proteomics Analysis of Host Responses to P. acnes Infection In Vivo. Proteomics, 2008, 8(16):3406-3415.
*56. Nakatsuji, T., Liu, Y.T., Huang, C.P., Gallo, R.L., and Huang, C. -M. Antibodies Elicited by Inactivated P. acnes-based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris. J. Investigative Dermatology, 2008, 128(10):2451-2457. PMID: 18463682
*57. Nakatsuji, T., Liu, Y.T., Huang, C.P., Gallo, R.L., and Huang, C. -M. Vaccination targeting a surface sialidase of P. acnes: Implication for new treatment of acne vulgaris. PLoS ONE, 2008, 3(2): e1551. PMID: 18253498
*58. Huang, C.P., Liu, Y.T., Nakatsuji, T., Shi, Y., Gallo, R.L., Lin, S.B., and Huang, C. -M. Proteomics integrated with vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes. Proteomics Clin. Appl. 2008, 2(9): 1234-1245.
**59. Huang, C. -M, et. al. A Peptide with ProGln C-terminus in the Human Saliva Peptidome Exerts Bactericidal Activity Against Propionibacterium acnes. Antimicrob Agents Chemother., 2008, 52(5):1834-1836.
*60. Fang, J. Y., Liu, P. F., and Huang, C. -M. Decreasing systemic toxicity by via transdermal delivery of anticancer drugs. Curr Drug Metab., 2008, 9(7):592-597.
*61. Chen, S.T., et. al. and Huang, C.-M. Breast cancer microenvironment: Proteomics highlights the treatments targeting secretome. J. Proteome Res., 2008, 7(4):1379-1387. PMID: 18290608
**62. Huang, C. -M., et. al. In vivo tumor secretion probing via ultrafiltration and tissue chamber: Implication for anti-cancer drugs targeting secretome. Recent Patents Anticancer Drug Discov. 2008, 3 (1):48-54. PMID: 18289123
*63. Lee, W.R., et. al. Huang, C.-M., and Fang, J.Y. Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control Release, 2008, 24;128(3):200-8. PMID: 18471920
*64. Liu, Y.-T., Lin, S.-B., Huang, C.-P., and Huang, C. -M. A Novel Immunogenic Spore Coat-Associated Protein in Bacillus Anthracis: Characterization via Proteomics Approaches and a Vector-Based Vaccine System. Protein Expr Purif., 2008, 57(1):72-80. PMID: 18029197
**65. Shu, C.-W., and Huang, C.-M. HSP70s: from tumor transformation to cancer therapy. Clin. Med.: Oncol. 2008, 2:335-345.
*66. Shi, Y., et al. and Huang, C.-M. Quantitative proteomes and in vivo secretomes of progressive and regressive UV-induced fibrosarcoma tumor cells: Mimicking tumor microenvironment using a dermis-based cell-trapped system linked to tissue chamber. Proteomics. 2007, 7(24):4589-4600.
**67. Nakatsuji, T., and Huang, C. -M. Potential Targets of P. acnes for New Treatments of P. acnes -Associated Diseases. Current Proteomics, 2007, 4(3):157-161.
**68. Huang, C. -M. Topical vaccination: the skin as a unique portal to adaptive immune responses. Springer Semin Immunopathol., 2007, 29(1):71-80. PMID: 17621956
**69. Huang, C. -M. In vivo secretome sampling technology for proteomics. Proteomics Clin. Appl. 2007, 1(9):953-962.
**70. Yang, S., Huang, C.-M. Recent advances in protein profiling of tissues and tissue fluids. Expert Rev Proteomics. 2007, 4(4):515-529. PMID: 17705709
**71. Liu, Y. -T., Huang, C. -M. In Vivo Sampling of Extracellular {beta}-Thymosin by Ultrafiltration Probes. Ann N Y Acad Sci. 2007, 12:104-113. PMID: 17495246
*72. Huang, C. -M., Ananthaswamy, HN., Barnes, S., Ma, Y., Kawai, M., and Elmets, CA. Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses. Proteomics, 2006, 6(22):6107-6116. PMID: 17051643
*73. Huang, C. -M., Wang, C.-C., Barnes, S., and Elmets, CA. In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics, 2006, 6(21):5805-5814. PMID: 17001601
*74. Huang, C. -M., Wang, C.-C., Kawai, M., Barnes, S., and Elmets, CA. Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics. Mol Cell Proteomics. 2006, 5(3):523-532.
*75. Huang, C. -M., Wang, C.-C., Kawai, M., Barnes, S., and Elmets, CA. In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics. J. Chromatography A., 2006, 109(2):144-151. PMID: 16376900
**76. Huang, C. -M., et. al. Proteomic characterization of skin and epidermis in response to environmental agents, Expert Rev. Proteomics, 2005, 2(5):809-820. PMID: 16209658
*77. Huang, C. -M., et. al. A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen, Proteomics, 2005, 5(4):1013-1023.
**78. Huang, C,-M., et. al. Prospective highlights of functional skin proteomics. Mass Spectrometry Review 2005, 25(5): 647-660.
**79. Huang, C. -M., Elmets, CA., Tang, D. -C., Li, F., and Yusuf, N. Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs. Genomics, Proteomics, Bioinformatics. 2004, 2(3):143-151.
*80. Huang, C.-M. Comparative proteomics analysis of human whole saliva. Archives of Oral Biology, 2004; 49(12) 951-962.
*81. Huang, C.-M., Foster, KW., DeSilva TS, Van Kampen, KR, Elmets, CA and Tang DC. 2004. Identification of Bacillus anthracis proteins associated with germination and early outgrowth by proteomic profiling of anthrax spores. Proteomics, 2004, 4(9):2653-2661. PMID: 15352240
82. Wu, YT., Jiaang, WT., Lin, KG., Huang, C.-M., et. al. A new N-acetylgalactosamine containing peptide as a targeting vehicle for mammalian hepatocytes via asialoglycoprotein receptor endocytosis. Curr Drug Deliv. 2004, 1(2):119-127.
*83. Huang, C. -M., et. al. Comparative proteomic profiling of murine skin. J. Investigative Dermatology, 2003; 121(1):54-64.
84. Huang, Y.-H, Chang, A.-Y, Huang, C.-M, et. al. Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells. Proteomics, 2002; 2(9): 1220-1228.
*85. Chen, S.-T., Pan, T.-L., Tsai, Y.-C. and Huang, C.-M. Proteomics reveals protein profile changes in doxorubicin-treated MCF-7 human breast cancer cells. Cancer Letters, 2002; 181: 95-107.
86. Huang, C.-M., et. al. Proteomics analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-KDa chromogranin B-derived fragment during neuronal differentiation. Molecular Brain Research, 2001; 92: 181- 192.
87. Chang, A. Y.-M., Huang, C.-M., et. al. Involvement of noradrenergic innervation from Locus Coeruleus to hippocampal formation in negative feedback regulation of penile erection in the rat. Hippocampus, 2001; 11(6): 783-792. PMID: 11811673
88. Chang, A. et. al., Huang, C.-M., and Chan, S.H.-H. Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat. J. Biomed. Sci., 2001; 8: 475-483. PMID: 11702011
89. Pan T.-L, Goto S, Lord R, Huang Y.-C, Huang C.-M, Wang P.-W, et al., Proteome analysis in liver transplantation.Transplant Proc. 2001,33(1-2):156. PMID: 11266756
90. Huang, C.-M., et. al. Specific delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis. Chemistry & Biology, 2000; 7:453-467. PMID: 10903942
91. Chu, P.-W., Yap, M.-N., Huang, C.-M., et al. A proteomic analysis of secreted proteins from xylan-induced Bacillus sp. Strain K-1. Electrophoresis, 2000; 21:1740-1745.
92. Huang , C.-M., and Kao, L-S. Nerve growth factor, epidermal growth factor and insulin differentially potentiate ATP-induced [Ca2+]I rise and dopamine secretion in PC12 cells. J. Neurochemistry, 1996; 66:124- 130. PMID: 8522943
93. Huang, C.-M., Tsay, K-E., and Kao, L.-S. Role of Ca2+ in differentiation mediated by nerve growth factor and dibutyryl cyclic AMP in PC 12 cells. J. Neurochemistry, 1996; 67:530-539. PMID: 8764577
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