專任教師-系統生物與生物資訊組   首頁 師資介紹 專任教師-系統生物與生物資訊組
劉淑貞 助理教授 Shu-Chen Liu
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學經歷


Education:

2009   Ph.D.     國防醫學院/中央研究院/國家衛生研究院合辦,生命科學研究科所

2000   M.S.   國立陽明大學醫學工程暨技術學院,放射醫學科學研究所


Experience:

2016-present      Assistant professor

                           (Department of Biomedical Sciences and Engineering,

                           National Central University)

2015-2016/01  Assistant research scholar

                            (Department of Biomedical Sciences and Engineering,

                            National Central University)

2009-2015      Postdoctoral research fellow

                            (Molecular Medicine Research Center, Chang Gung University)

2001-2009       Ph.D. program

  (Division of Molecular and Genomic Medicine,

                            National Health Research Institutes)


Professional Memeberships:

2004-Present         Taiwan Society for Therapeutic Radiology and Oncology (台灣放射腫瘤學會)



Honors

- 2017 The 22nd Taiwan Joint Cancer Conference Award

-2014 Awards of The Cancer Prevention & Treatment Foundation

-2014 The 19th Taiwan Joint Cancer Conference Poster Award

-2011 NHRI Outstanding Paper Award

-Awarded for excellent thesis in 2009 NHRI Research Day


實驗室研究主題 (Research Interests)
1.腫瘤微環境(Tumor microenvironment)
2.鼻咽癌轉移機轉(Nasopharyngeal carcinoma metastasis)
3.EB病毒與鼻咽癌癌化研究(Epstein-Barr virus-associated carcinogenesis)
4.跨領域癌症生物應用(Interdisciplinary applications of physics and cancer biology)



論文著作區

期刊論文

 Liu SC*, Hsu T, Chang YS, Jiang SS, Chung AK , OuYang CN, Yuh CH , Hsueh C , Liu YP
, Tsang NM. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination
through modulating YAP1-FAK/PXN signaling. Nature Communications ((2018) 9: 5105).
(IF: 12.353, ranking:3/64, Multidisciplinary Sciences) (First and corresponding author).


Chen HY, Hsiao YT, Liu SC, Hsu T, Woon WY, and I L*. Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Physical Review Letters. 2018, 121(1): 018101. 

Wu TS1, Wang LC1, Liu SC1, Hsu TY, Lin CY, Feng GJ, Chen JM, Liu HP, Chung IC, Yen TC, Chang YS, Liao SK, Chang C, Chow KP. EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model. J Immunol. 2015 May 1;194(9):4577-87 (1co-first author).
 
Hsu CW, Yu JS, Peng PH, Liu SC, Chang YS, Chang KP, Wu CC. Secretomic profiling of primary cells reveals that THBS2 is a salivar biomarker of oral cavity squamous cell carcinoma. J Proteome Res. 2014 Nov 7;13(11):4796-807. 

Liu SC and Chang YS. Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis. Molecular & Cellular Oncology. 2014 Jul 15 1(1): e29900. 

Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS*. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest. 2013 Dec 2;123(12):5269-83. 

Liu HP, Chen CC, Wu CC, Huang YC, Liu SC, Liang Y, Chang KP, Chang YS.
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 2012 May;8(5): e1002690. 

Peng PH, Wu CC, Liu SC, Chang KP, Chen CD, Chang YT, Hsu CW, Chang YS, Yu JS. Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J Proteomics. 2011 May 1;74(5):744-57. 

Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res. 2009 Aug 1;69(15):6122-30.  

Chen HC, Ma HI, Sytwu HK, Wang HW, Chen CC, Liu SC, Chen CH, Chen HK, Wang CH. Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. J Neurosci Res. 2010 Nov 15;88(15):3308-18. 

Jiang SS, Chang IS, Huang LW, Chen PC, Wen CC, Liu SC, Chien LC, Lin CY,
Hsiung CA, Juang JL. Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus. J Virol. 2006 Sep; 80(18):8989-99. 

Wen CC, Wu YJ, Huang YH, Chen WC, Liu SC, Jiang SS, Juang JL, Lin CY, Fang WT, Hsiung CA, Chang IS. A Bayes regression approach to array-CGH data. Stat Appl Genet Mol Biol. 2006;5: Article3. 

會議論文
Lee PJ and Liu SC*. SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14). 

Kao MZ, Lee PJ, Chung MC, Chen CC* and Liu SC*. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14). 

PJ and Liu SC*. The potential role of YAP1 protein in AZD0530-mediated suppression of human fibroblast activation (The 23rd Taiwan Joint Cancer Conference, 2018/5/5~6).

Kao MZ, Chung MC, Chen CC, Liu SC*. Magnet Halbach Arrays-Mediated Effects in Carcinoma Cells. (The 23rd Taiwan Joint Cancer Conference, 2018/5/5~6).

Liu SC*, Hsu T, Yuh CH, Tsang NM. Cytoplasmic LIF Reprograms Cancer Invasive Modes to Facilitate Metastasis and Enhance Multidrug Resistance. The 22nd Taiwan Joint Cancer Conference (2017, May). (優秀論文獎).

Liu SC*, Tsang NM, Hsu T, Chang YS(2016, Aug). Leukemia inhibitory factor drives invadopodia formation and genome instability. 2016 17th International Symposium on EBV and associated diseases (Zurich, Switzerland). 

Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Juang JL, Chow KP, Chang YS. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance (Oral presentation). 2014 Academic Conference of TASTRO & The 4th Annual Meeting of TAROS (Awards of The Cancer Prevention & Treatment Foundation). (優秀論文獎)

Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Poster presentation). 2014 16th International Symposium on EBV and Associated Diseases (Brisbane, Australia).

Liu SC, Tsang NM, Chang KP, Hsueh C, Chang YS. Pro-inflammatory cytokines promote nasopharyngeal carcinoma progression through the activation of mTORC1/p70S6K1 (Oral & poster presentation). 2014 The 19th Taiwan Joint Cancer Conference. (優秀論文獎)

Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y, Chang YS. LIF regulates p70S6K to promote progressiveness and radioresistance of NPC (Poster presentation). EBV 50th Anniversary, 23rd - 25th March 2014, Keble College Oxford. 

Liu SC. Functional monitoring of thrombin-induced responses in cancer cells (Oral presentation, invited speaker). xCELLigence Symposium 2010 Beijing, China.

Liu SC, YM, Jiang SS, Chang JL, Hsiung CA, Wang CH, Juang JL. G12-dependent pathway promotes tumorigenesis and metastasis of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization (Oral presentation). 2009 Research Day, National Health Research Institutes, Taiwan.

研究計畫區

計畫

1. 榮台聯大研究計畫(2019/1/1~2019/12/31): VGHUST108-G4-3-1 (主持人)。
2. 科技部專題計畫:含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調
控 (Most 107-2314-B-008-003-)(主持人)。
3. 榮台聯大研究計畫(2018/1/1~2018/12/31): VGHUST107-G4-2-1 (主持人)。
4. 科技部延攬研究學者計畫(2015/08/01~2018/07/31): EBV病毒調控脂肪細胞分化
並重建腫瘤微環境 (MOST -104-2321-B-008-003-MY3)(主持人)。
5. 國際科技人士短期訪問計畫(計畫編號:106WCSFA0700029)(國立中央大學生醫
科學與工程學系主辦「2017 生物醫學工程科技研討會」暨「科技部醫學工程學門
成果發表會」。
6. 榮台聯大研究計畫(2017/1/1~2017/12/31): VGHUST106-G4-2-1白血病抑制因子

重建侵犯模式增強癌侵犯性 (主持人) 。



實驗室成員

生醫系生醫班碩士班高銘澤(Ming-Ze Kao)同學

--26屆細胞及分子生物新知研討會(The 26th Symposium on Recent Advances in Cellular and Molecular Biology,(Jan 23rd ~ 25th, 2019)

--國立中央大學107學年度誠樸獎學金

--國際研討會論文. Ming-Ze Kao, Po-Ju Lee, Min-Che Chung, Chien-Chang Chen* and Shu-Chen Liu*. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14).

--第二十三屆台灣癌症聯合學術年會 (The 23rd Taiwan Joint Cancer Conference). Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, Shu-Chen Liu*. Magnet Halbach Arrays-Mediated Effects in Carcinoma Cells (2018/5/5~6).

--第33屆生物醫學聯合學術年會(The 33th JACBS Conference). Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, Shu-Chen Liu*. Magnet Halbah Arrays Induce Cell Cycle Redistribution of Cancer Cells (2018/03/24~03/25).

--「2017生物醫學工程科技研討會」暨「科技部醫學工程學門成果發表會」

Ming-Ze Kao, Min-Che Chung, Chien-Chang Chen, and Shu-Chen Liu. Magnet Halbach Arrays Induce Cell Cycle Redistribution of Cancer Cells.


生醫系大學部五年一貫碩士生李柏儒(Po-Ju Lee)同學

--26屆細胞及分子生物新知研討會(The 26th Symposium on Recent Advances in Cellular and Molecular Biology,(Jan 23rd ~ 25th, 2019)

--國立中央大學107學年度第一學期優秀學生獎學金

--科技部107年度大專生研究計畫(計畫編號:107-2813-C-008-059-B): Mechanistic study of saracatinib-mediated effects on tumor microenvironment.

--國際研討會論文. Lee PJ and Liu SC*. SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment. The 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention. Lisbon, Portugal (2018, June10-14).

--第二十三屆台灣癌症聯合學術年會(The 23rd Taiwan Joint Cancer Conference). Lee PJ and Liu SC*. The potential role of YAP1 protein in AZD0530-mediated suppression of human fibroblast activation (2018/5/5~6).

--第33屆生物醫學聯合學術年會(The 33th JACBS Conference). Lee PJ and Liu SC*. Yes-associated Protein 1 regulates activation of Cancer-associated Fibroblasts (2018/03/24~03/25).

--中研院生醫所暑期實習(2017/7~2017/9).


生醫系大學部專題生: 林欣毅,劉子彤,隋昀華


專利區


專利

1.   Potentiation of nasopharyngeal cancer radiotherapy by inhibitors of leukemia inhibitory factor  (美國)( US9,194,872 B2; 專利期限2015/11 2034/04)

2.   評估癌症於治療後情況的方法及其相關應用 (中國)( CN 104623663 A; 專利期限2017 /7/142034/1/26)

3.   鼻咽癌治療的醫藥  (台灣,發明第I486172,專利期間: 2015/06~2033/11)