專任教師-生物醫學工程組   首頁 師資介紹 專任教師-生物醫學工程組
李宇翔 副教授 Yu-Hsiang Lee
從聘系所: 化學工程與材料工程學系
專線電話:03-4227151轉 27755
傳真電話:
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學經歷

Education/Experience:

2014-           :  Associate Professor, National Central University

2010 - 2014 :  Assistant Professor, National Central University

2008 - 2010 :  Postdoctoral Fellow, UCLA Dental Research Institute (CA, USA)

2006 - 2008 :  Research Scientist, Sierra Sciences LLC (NV, USA)

2002 - 2006 :  Research Assistant (in Ph.D Program), Department of Chemical Engineering, University of Southern California (CA, USA)

Research Interests:

[1] Biomaterials

[2] Nanomedicine/Drug Delivery

[3] Photobioreactor Engineering

[4] Mechanotransductional Biology

論文著作區

Selected Journal paper (*Corresponding author)

  1. Lee Y-H*, Lin Y-C. (2018/04) Anti-EGFR Indocyanine Green-Mitomycin C-loaded Perfluorocarbon Double Nanoemulsion: A Novel Nanostructure for Targeted Photochemotherapy of Bladder Cancer Cells. Nanomaterials 8: 283. (SCI) (MOST 106-2221-E-008-060)
  2. Lee Y-H*, Lai C-W, Cheng Y-C*. (2018/06) Fluid Shear Stress Induces Cell Cycle Arrest in Human Urinary Bladder Transitional Cell Carcinoma through Bone Morphogenetic Protein Receptor-Smad1/5 Pathway. Cellular and Molecular Bioengineering 11: 185-195. (SCI) (MOST 106-2221-E-008-060)
  3. Lee Y-H*, Weng T-C. (2018/03) Development of Synthetic Perfluorinated Photobioreactor System for Simultaneous Carbon Dioxide Separation and Promotion of Microalgae Growth and Productions. Journal of Chemical Technology and Biotechnology 93: 1065-1074. (SCI) (MOST 106-2622-E-008-011-CC2)
  4. Lee Y-H*, Yeh C-H. (2018/01) Laminar Shear Stress Inhibits High Glucose-Induced Migration and Invasion in Human Bladder Cancer Cells. In Vitro Cellular & Developmental Biology - Animal 54: 120-128. (SCI) (MOST 106-2221-E-008-060)
  5. Lee Y-H*, Ma Y-T. (2017/05) Synthesis, Characterization, and Biological Verification of Anti-HER2 Indocyanine Green-Doxorubicin-Loaded Polyethyleneimine-Coated Perfluorocarbon Double Nanoemulsions for Targeted Photochemotherapy of Breast Cancer Cells. Journal of Nanobiotechnology 15(1): 41 (SCI) (MOST 105-2221-E-008-014)
  6. Lee Y-H*, Chang D-S. (2017/04) Fabrication, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Doxorubicin-Encapsulated PEG-b-PLGA Copolymeric Nanoparticles for Targeted Photochemotherapy of Breast Cancer Cells. Scientific Reports 7: 46688 (SCI)  (MOST 105-2221-E-008-014) (105CGH-NCU-A2)
  7. Lee Y-H*, Li P-H. (2017/02) Using Resonant Ultrasound Field-Incorporated Dynamic Photobioreactor System to Enhance Medium Replacement Process for Concentrated Microalgae Cultivation in Continuous Mode. Chemical Engineering Research and Design 118(2017): 112-120 (SCI) (MOST 105-2221-E-008-014) (105CGH-NCU-A2).
  8. Lee Y-H*, Lai Y-H. (2016/12) Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells. PLOS ONE 11(12): e0168192 (SCI) (MOST 105-2221-E-008-014)
  9. Lee Y-H*, Lee C-C, Huang C-H, and Ho F-M*. (2016/08) Laminar Shear Stress Promotes Nicotine-Induced Inflammation and Hemostatic Expression in Human Endothelial Cells. Cellular and Molecular Bioengineering 9(3): 466-477 (SCI) (MOST 104-2221-E-008-095).
  10. Lee Y-H*, Lai Y-H. (2015/09) Fabrication and Characterization of HER2 Cell Receptor-Targeted Indocyanine Green-Encapsulated Poly(Lactic-co-Glycolic Acid) Nanoparticles. Peertechz Journal of Biomedical Engineering 1(1): 015-020. (MOST 104-2221-E-008-095).
  11. Lee Y-H, Chen R-S, Chang N-C, Lee K-R, Huang C-T, Huang Y-C, and Ho F-M*. (2015/09) Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells. Annals of Biomedical Engineering 43(9): 2220-2230. (SCI) (NSC 101-2221-E-008-018).
  12. Lee Y-H*, Wu Z-Y. (2015/08) Enhancing Macrophage Drug Delivery Efficiency via Co-Localization of Cells and Drug-Loaded Microcarriers in 3D Resonant Ultrasound Field. PLOS ONE 10(8): e0135321. (SCI) (104CGH-NCU-A1)
  13. Lee Y-H*, Yeh Y-L. (2015/07) Reduction of Oxygen Inhibition Effect for Microalgal Growth Using Fluoroalkylated Methoxy Polyethylene Glycol-Stabilized Perfluorocarbon Nano-Oxygen Carriers. Process Biochemistry 50(7): 1119-1127. (SCI) (NSC 101-2622-E-008-014-CC3).
  14. Lee Y-H*, Yeh Y-L. (2014/08) Using Polyethylene Glycol as Nonionic Osmoticum to Promote Growth and Lipid Production of Marine Microalgae Nannochloropsis oculata. Bioprocess and Biosystems Engineering 37(8): 1669-1677. (SCI) (NSC 101-2622-E-008-014-CC3)
  15. Lee Y-H*, Yeh Y-L, Lin K-H, and Hsu Y-C. (2013/08) Using Fluorochemical as Oxygen Carrier to Enhance the Growth of Marine Microalga Nannochloropsis oculata. Bioprocess and Biosystems Engineering 36(8): 1071-1078. (SCI) (NSC 100-2622-E-008-013-CC3)
  16. Lee Y-H*, Tseng C-S, and Wei Y-L. (2012/11) Fabrication and Characterization of CdSe/ZnS Quantum Dots-Doped Polystyrene Microspheres Prepared by Self-Assembly. Journal of Materials Research 27(22): 2829-2836. (SCI)
  17. Lee Y-H, Joshipura K, Vergara JL, and Wong DT*. (2012/03-06) Detection of Type II Diabetes Mellitus Using Salivary Transcriptomic Biomarkers. Genomic Medicine, Biomarkers and Health Sciences 4: 7-11. (SCOPUS)
  18. Lee Y-H, Kim JH, Zhou H, Kim BW, Wong DT*. (2012/04) Salivary Transcriptomic Biomarkers for Detection of Ovarian Cancer: For Serous Papillary Adenocarcinoma. Journal of Molecular Medicine 90(4): 427-434. (SCI) 
  19. Lee Y-H, Zhou H, Reiss JK, Yan X, Zhang L, Chia D, and Wong DTW*. (2011/09) Direct Saliva Transcriptome Analysis. Clinical Chemistry 57(9): 1295-1302 (SCI)
  20. Lee Y-H, Peng C-A*. (2009/12) Effect of hypotonic stress on retroviral transduction. Biochemical and Biophysical Research Communications 390(4) 1367-1371. (SCI)
  21. Lee Y-H, Wong DT*. (2009/08) Saliva: An emerging biofluid for early detection of diseases. American Journal of Dentistry 22(4): 241-248. (SCI)
  22. Lee Y-H, Peng C-A*. (2007/05) Nonviral Transfection of Suspension Cells in Ultrasound Standing Wave Fields. Ultrasound in Medicine and Biology 33(5): 734-742. (SCI)
  23. Lee Y-H, Lai C-Y, Li P-C, Peng C-A*. (2005/12) Ultrasound-Mediated Perfluorocarbon Microbubbles Bursting for Gene Transfection. Journal of Medical and Biological Engineering 25(4): 153-158. (SCI).
  24. Lee Y-H, You J-O, Peng C-A*. (2005/03-04) Retroviral transduction of adherent cells in resonant acoustic fields. Biotechnology Progress 21(2): 372-376. (SCI)
  25. Lee Y-H, Peng C-A*. (2005/04) Enhanced retroviral gene delivery in ultrasonic standing wave fields. Gene Therapy 12(7): 625-633 (SCI)
研究計畫區

科技部計畫

[1] NSC 100-2622-E-008-013-CC3 (PI/產學)

[2] NSC 101-2221-E-008-018- (PI/專題)

[3] NSC 101-2622-E-008-014-CC3 (PI/產學)

[4] NSC 102-2221-E-008-012 (PI/專題)

[5] MOST 104-2221-E-008-095- (PI/專題)

[6] MOST 105-2221-E-008 -014- (PI/專題)

[7] MOST 105-2221-E-008 -045- (Co-PI/專題)

[8] MOST 106-2622-E-008-011-CC2 (PI/產學)

[9] MOST 106-2221-E-008 -046- (Co-PI/專題)

[10] MOST 106-2221-E-008-060- (PI/專題)

[11] MOST 107-2622-E-008 -005 -CC3 (PI/產學)

[12] MOST 107-2221-E-008-043 (PI/專題)

建教合作計畫

[1] PTH10219 (中央大學-衛福部桃園醫院 建教合作計畫) (Co-PI/專題)

[2] 105CGH-NCU-A2 (中央大學-國泰醫院聯合研發中心 建教合作計畫) 子計畫#3主持人

[3] VGHUST107-G4-1-2 (榮總台灣聯合大學合作研究計畫) 子計畫#2主持人

專利區

[1] 李宇翔,葉昱伶。培養擬球藻之系統。中華民國專利 發明第I 487481號。(2015-2033)

[2] 宇翔,馬韻婷。藥物丸粒、其醫藥組合物及其用途。經濟部智慧財產局審查案號:105134788,申請日: 20161027日,審查中